Fermentation for Special Small Molecules

• Fermentation for APIs
• Fermentation for Bioactive Metabolites
• Fermentation for Small Molecule Toxins

Different from conventional synthetic small molecules, the small molecules obtained through fermentation, produced in the culture of living cells, are usually more bioactive and cost-effective. The development of fermented chemicals could better meet the research needs in various fields, including pharmaceuticals, food, cosmetics, animal feed, and material science.

One of BOC Sciences' focus is the expression of small molecules via fermentation. We have been exploring systems that allow the expression of small molecules that were previously only accessible via chemical synthesis.

Our Services

• We offer extraction and analysis services of the fermentation products of a primitive strain.
• According to the target small molecule provided by customers, we have the ability to optimize the selection of strains and design the experiment scheme.
• We specialize in combining synthetic chemistry with fermentation and have successfully developed many chiral APIs and intermediates.
• We provide a one-stop fermentation, analysis and purification service for your target small molecules.
• Our Strain Technology includes Genetic engineering directed breeding, Physicochemical factors induced breeding, High throughput Screening technique, Protoplast fusion, Space breeding technology and Strain preservation and identification.
• Capable of effectively improving bacteria, actinomycetes, mold, yeast, etc., and ability to transform primitive strain into industrializable strain.
• Development of hybrid microbial active substances with genetic engineering technology and combined biotransformation technology.

Our Capability

• Extensive Experience
  With more than 20 years of experience in the aspect of traditional strain breeding and fermentation production.
• Identification Capability
  Microbial morphology and physiology
  DNA base composition analysis (G+C mol%)
  DNA-DNA Hybridization
  rDNA homology analysis (16S rDNA, 26S rDNA D1/D2, 5.8S rDNA ITS region sequence analysis)
  DNA based strain typing (RFLP, Whole genome sequencing, PCR-based DNA fingerprinting etc.)
• Comprehensive Analytical Capabilities
  Fully characterize the product with the physical and chemical properties
  Development, optimization, qualification, and validation of test methods
  Compound characterization: GC-MS, LC-MS, NMR, XRD, etc.
  Lot release testing: HPLC, UPLC, IR, UV, etc.
  Stability study
  Troubleshooting

  Preservation Methods

  Regular transplantation method
  Sand pipe method
  Liquid paraffin method
  Freeze vacuum drying method
  Ultra-low temperature freezing method
  Liquid nitrogen ultra-low temperature freezing method, etc.
  
  

  Fermentation synthesis process of target small molecules

  Customer advisory
  Project discussion, fermentation formulation (customers can provide fermentation strains)
  Strain development and improvement
  Lab-scale fermentation, fermentation and purification parameters optimization
  Target small molecule extraction and purification