Fermentation Products

As a leading CDMO, BOC Sciences' fermentation products are used in various industries such as pharmaceutical, food and fragrance, agriculture, nutraceutical and many others. We provide services for strain development, metabolic pathway engineering, protein expression, enzyme engineering and fermentation process development. We have the ability to perform large-scale fermentation to produce natural products origin from bacteria, fungi, plants, and others. And our manufacturing systems comply with good manufacturing practice, which are well suited to meet the needs of our customers around the world.

The production of common and useful natural products such as peptides, lipids, flavonoids, terpenoids, polysaccharides, oligonucleotides, etc. is covered in our fermentation services.

Fermentation for Peptides

The applications of peptides include peptide drugs, peptide drug carriers, tissue engineering materials and peptide nutrition food. The production methods of peptides mainly include combinatorial chemistry, enzymatic hydrolysis, genetic engineering and microbial fermentation. Fermentation is a method of extracting peptides from metabolites produced by cultured microorganisms. Microbial fermentation technology provides a novel way to produce bioactive peptides for pharmaceutical, food ingredient, nutraceutical industry. In addition, antimicrobial peptides (AMPs), which are ribosomally produced by microbes, plants and animals, can be served as alternatives to conventional antibiotics to counteract antibiotic resistant.

Fermentation Products

Fermentation for Lipids

There are some microorganisms in nature that can produce lipid, such as yeasts, molds, bacteria and algae. Under certain conditions, they use carbohydrates, hydrocarbons and common fats as carbon sources, nitrogen sources, supplemented by inorganic salts to produce fats and other commercially valuable lipids. BOC Sciences produces custom lipids for food and nutraceutical industries. In addition, microbial lipids can replace vegetable lipids to produce biodiesel through biotransformation.

Fermentation Products

Fermentation for Flavonoids and Phenolics

Flavonoids are a series of plant secondary metabolites derived from phenylpropane metabolic pathway through flavonoid synthesis pathway. Flavonoids are the largest group of naturally occurring phenolic compounds, which occurs in different plant parts both in free state and as glycosides. With the development of synthetic biology and metabolic engineering, such as dihydroflavones, flavones, isoflavones, flavonols, anthocyanidins and flavanones can be synthesized by engineering yeast, E. coli or other microorganisms. These compounds have antioxidant, anti-inflammatory, anti-tumor, improve blood circulation and other physiological functions, which have broad application prospects in health care products, cosmetics and medicine industries.

Fermentation Products

Fermentation for Terpenoids and Carotenoids

Terpenoids otherwise known as isoprenoids are a large and diverse class of naturally occurring compounds derived from five carbon isoprene units. Terpenoids are the largest class of plant secondary metabolites. They perform several important functions in plants and humans and have substantial pharmacological bioactivity. Carotenoids, also called tetraterpenoids, are a class of naturally occurring pigments synthesized by plants, algae, and photosynthetic bacteria.

Terpenoids	Number of isoprene units	General formula	Examples
Monoterpenoids	2	C₁₀H₁₆	Carvone, Citral
Diterpenoids	4	C₂₀H₃₂	Paclitaxel, Retinol
Triterpenoids	6	C₃₀H₄₈	Sterols, Squalene
Tetraterpenoids	8	C₄₀H₆₄	Carotenoids

Fermentation Products

Fermentation for Polysaccharides

The microorganisms can produce large amounts of polysaccharides in the presence of surplus carbon source. Microbial polysaccharides have immense commercial importance. They are employed in the stabilization of foods, and production of several industrial and pharmaceutical compounds. Degradation of polysaccharides produces a large number of oligosaccharides that are conducive to host health. The production process of microbial polysaccharides is mostly carried out by batch culture fermentation. In contrast to the production of plant polysaccharides, production of microbial polysaccharides is well controlled and can be continued throughout the year.

Fermentation Products

Fermentation for Oligonucleotides

Oligonucleotides are short strands of genetic sequences, the building blocks of nucleic acids-such as those in DNA and RNA. Oligonucleotides extracted from microorganisms are used as antiviral agents, immunostimulators, and flavour enhancers. In recent years, considerable advances have been made in the development of oligonucleotide drugs. Unlike most biological drugs that target proteins, oligonucleotides target errors in the genetic code and are used to treat rare diseases that have been previously untreatable. With the development of recombinant and bioengineering technology, efficient, large-scale, and cost-effective fermentation production of oligonucleotides has become possible.

Fermentation Products

Fermentation for Recombinant Proteins

Recombinant protein is a protein encoded by recombinant DNA. Modification of the gene by recombinant DNA technology can lead to expression of a mutant protein. Recombinant proteins are formed by transfecting foreign genes into a host cell, and Escherichia coli is one of the organisms of choice for the production of recombinant proteins. Recombinant proteins are commonly used to produce pharmaceutical products, protein-based polymers for drug delivery, antibodies and enzymes for disease treatment, protein scaffolds for tissue engineering, and many other uses.

Organic Acids

Fermentation for Organic Acids

Organic acids can be commercially produced through fermentation strategies based on biological pathways, which have a variety of uses in the pharmaceutical, food, cosmetic and textile industries. Organic acids produced by fermentation can also be used to make bioplastics. Microbial fermentation for the production of organic acids is highly productive, environmentally friendly and allows the use of economical substrates. Methods such as microbial metabolic engineering and recombinant DNA techniques have enabled the development of strains with high productivity of organic acids.