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N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic that could be a potential cytotoxic DNA-binding agent in antibody-drug-conjugation (ADC). Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis.

It is produced by the strain of Nocardia sp. C-15003(N-1). It has the function of anti-tumor, anti-plant pathogenic fungi, skin fungi and protozoa, and has no antibacterial activity.

Mitomycin C is a quinone mitomycin antibiotic produced by Str. caespitosus NRRL 2564. It has antibacterial, antimycobacterial and antiviral activities. And it has an inhibitory effect on tumors.

Illudin S is a natural sesquiterpene agent with strong anti-tumour activity. Illudin S inhibits DNA synthesis via an unknown mechanism.

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an anti-infective and antiangiogenic agent.

It is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

Thailanstatin A is a splicesosome inhibitor that acts via suppressing RNA-polymerase II. It is effective against cancers, and can be used as a payload for ADCs.

Deoxymulundocandin is an echinocandin antifungal agent isolated from Aspergillus sydowii.

Didemnin B is a cyclic depsipeptide isolated from the extract of Trididemnum solidum. It exhibits antiviral and antineoplastic effects.

Spinosyn D is a spinosoid that is a minor component of spinosad isolated from sugarcane S. spinosa. It is a potent insecticide for crop pathogens and ectoparasite control on animals.

Ectoine is a natural compound found in several bacteria such as halophilic microorganisms and acts as an osmoprotectant. It can be used as a skin care ingredient.

K252a, an analog of staurosporine, has been found to be a protein kinase inhibitor and exhibit antitumor activity at some extent.

Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase.

a potent anti-fungal antibiotic. Leptomycin B is an inhibitor of export protein CRM1.

Dihydrocarminomycin is an anthracycline antibiotic that can be produced by Streptomyces atroviolaceus DS 8938, Str. coeruleorubidus DS 8899, DS 31723, DS 7126 and Str. bifurcus DS 23219.

Spinosyn L is a component of Spinosyns, a group of compounds produced from fermentation of two species of Saccharopolyspora. It exhibits insecticidal activities against many commercially significant species that cause extensive damage to crops and other plants.

It is an aminoglycoside antibiotic produced by the strain of Streptosporangium sibiricum. It has anti-bacterial effect and has an inhibitory effect on reticuloendothelial sarcoma RAB-1 and oncogenic AK/LY cells. Two times of the maximum tolerated dose of intravenous administration can inhibit OZH-5 tumor and lymphosarcoma Lic-1. It has very high DNA binding affinity and cytotoxicity against cancer cell lines.

Spinosyn A is the main component of the unusual hydrophobic macrolide complex isolated from Echinosaccharomyces. It is an effective pesticide for crop pathogens and control of ectoparasites of animals.

Daptomycin is a lipopeptide antibiotic produced by the soil saprotroph Streptomyces roseosporus. It is used to treat systemic infections and life-threatening infections caused by gram-positive organisms.

Spinosyn J is a component of Spinosyns, a group of compounds produced from fermentation of two species of Saccharopolyspora. It exhibits insecticidal activities against many commercially significant species that cause extensive damage to crops and other plants.