New Products

Dalbavancin is a semi-synthetic glycopeptide by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram-positive and multi-drug resistant isolates such as MRSA and MRSE.

Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs.

FR-901463 is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

FR-901465 is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

Ansamitocin derivative TN-006 is a derivative of Ansamitocin, a family of polyketide antibiotics comprising a naphthalene/benzene or napthaquinone/benzoquinone ring system bridged at nonadjacent positions by an aliphatic chain.

Ansamitocin PDM-3 is an ansamycin antibiotic isolated from Actinosynnema pretiosum, and exhibits antitumor activity.

Neocarzinostatin chromophore is a macromolecular chromoprotein enediyne antitumor antibiotic produced by Streptomyces macromomyceticus.

Epothilone C is a novel microtubule inhibitor and acts as an antineoplastic agent. Epothilones are originally isolated from cellulose-degrading myxobacterium Sorangium cellulosum.

Dov-Val-Dil-OH is an intermediate of dolastoxin, a cytotoxic liner peptide produced by Dolabbella auriclaria which exhibits potent antitumor activity.

Bafilomycins are a family of macrolide antibiotics isolated from Streptomycetes sp. They exhibits antitumor, antiparasitic, immunosuppressant and antifungal activity.

Subtilosin A is an antibiotic peptide produced by Bacillus subtilis 168.

Olivomycin is an antitumor antibiotic produced by Actinomyces (or Streptomyces) olivoreticuli. It is used for the treatment of testicular neoplasms, tonsillar tumors and reticulosarcoma with peripheral nodes.

Siomycin is a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G and aminoacyl-tRNA. It exhibits antitumor activity against certain cancer cell lines.

Stambomycin A is a macrolide antibiotic with promising antitumor activity.

Tallysomycin is an antitumor antibiotic complex produced by actinomycetes strain No. E465-94 with antibacterial and antifungal activity. It consists of two major components, A and B.

Jadomycin B is an angucyclic natural product produced by Streptomyces venezuelae ISP5230. It exhibits antimicrobial, antitumor activity and inhibits aurora-B kinase and DNA cleaving. It was also shown to be effective against a variety of staphylococci.

Megalomicins are a family of macrolide antibiotics produced by the soil bacterium Micromonospora megalomicea. They exhibit antiparasitic, antiviral and antibacterial activity, and are effective against both Gram-positive and Gram-negative bacteria.

Rhodomycin are a family of antibiotics produced by a red-pigmented mutant of Streptomyces griseus. They possess anti-gram-positive bacteria, anti-gram-negative bacteria and antifungal properties.

Exotoxin A is an exotoxin derived from Pseudomonas aeruginosa. It was shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2.

Polyoxorim is a member of the class of polyoxins that is isolated from the soil organism Streptomyces cacaoi var. asoensis. Polyoxorim exhibits fungicidal properties and may be used on rice, industrial grounds, golf courses and parks. It has a role as an EC 2.4.1.16 (chitin synthase) inhibitor and an antifungal agrochemical. It is a polyoxin and an antibiotic fungicide.