|Product Name / CAS / Description
Abierixin is a polyether antibiotic isolated from Streptomyces albus NRRL B-1865. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity.
Milbemycin α1 is a macrolide antibiotic produced by Str. hygroscopicus subsp. aureolacrimosus. It has insecticidal effects on agricultural harmful insects, pans, larvae, etc.
It is produced by the strain of Str. lasaliensis. It has anti-gram-positive bacteria, protozoa and mycobacterium activity. It is added to feed to prevent coccidiosis in chickens.
Tylosin is a 16-member-ring macrolide produced through the fermentation of Streptomyces fradiae, a species of actinobacteria found in soil. It is effective against gram-positive bacteria, Mycoplasma species and certain gram-negative bacteria. With other macrolides, tylosin inhibits protein synthesis by binding to the 50S subunit of the bacterial ribosome and disrupting aminoacyl-and peptidyl-tRNA transcription. This is believed to ultimately prevent the bacteria from reproducing.
The dominant member of a class of milbemycins; shows pronounced nematocidal and insecticidal activity
Bambermycin (flavomycin) is a complex of antibiotics obtained from Streptomyces bambergiensis and Streptomyces ghanaensis used as a food additive for beef cattle, dairy cattle, poultry and swine. The complex consists mainly of moenomycins A and C.
Dihydrostreptomycin sesquisulfate is a semi-synthetic aminoglycoside antibiotic. Dihydrostreptomycin sesquisulfate is a derivative of Streptomycin used to treat bacterial diseases in cattle, pigs and sheep.
Apicidin is a cyclic peptide antibiotic with broad-spectrum antiproliferative, antiparasitic and antiprotozoan activity. It is a histone deacetylase (HDAC) inhibitor with anti-angiogenesis and apoptosis-inducing effects.
It is a polyether antibiotic produced by Str. aureo faciens NRRL 5758. It has broad spectrum activity against gram-positive bacteria, anaerobic bacteria and mycoplasma. It also has antiviral and limited antifungal activity.
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, which is used as an antiparasitic drug for the treatment of certain parasitic roundworm infections. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection. Ivermectin is a mixture of mostly Ivermectin B1a (>80%) with some Ivermectin B1b (<20%), which are macrolides from Streptomyces avermitilis.
Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride channels, resulting in central nervous system toxicity. Fipronil can be used to kill parasites such as fleas and lice on cats and dogs.
Avilamycin is an antimicrobial agent that is active mainly against Gram-positive bacteria and is used against methicillin-resistant staphylococcus.
PF1022A, an anthelmintic cyclodepsipeptide isolated from cultured mycelia of Mycelia Sterilia, has very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. It has potent repellant activity against Ascaridiagalli in chicken. In vitro, it has activity against Trichinella spiralis and Nippostrongylus brasiliensis.
Lufenuron is a benzoylurea pesticide which inhibits the production of chitin in larval fleas.
Emodepside, also known as PF 1022-221, a semisynthetic derivative of PF1022A, is efficacious against a variety of gastrointestinal nematodes and used as an anthelmintic drug with broad-spectrum anthelmintic activity. Emodepside is an octapeptide drug that has been approved for use in cats.
Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms. Moxidectin can be used to prevent heartworm infection in dogs. Moxidectin is a semisynthetic derivative of nemadectin which is produced by fermentation by Streptomyces cyano-griseus.
Milbemycin oxime is a semi-synthetic macrolide. As a nematocide and insecticide in veterinary medicine, it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); Bile acid transporter: IC50 = 3.6 µM (human); TGR5: IC50 = 36.4 µM (human); HCT-116: IC50 >50 µM (human); GBM: IC50 >50 µM (human)
Doramectin is a derivative of ivermectin, which is an anthelmintic. Doramectin is an antiparasitic antibiotic produced by Streptomyces.
Nitenpyram, a natural product found in Streptomyces canus, is a nicotinic acetylcholine receptor (AchR) agonist used in veterinary medicine to treat parasites of livestock and pets.
Seramectin is a semi-synthetic abamectin derivative. Seramectin is an effective nematicide for the treatment of endoparasites and ectoparasites in domestic animals (especially cats and dogs). It can selectively bind to the chloride channel gated by the parasite's glutamate and disrupt neurotransmission, leading to paralysis and parasite death.
As a leading CDMO, BOC Sciences provides contract fermentation services for the production of bioactive metabolites that can be used in animal health industry. Our fermented bioactive metabolites, although not directly fed to animals, hold significant advantages for our customers participated in animal health. We are able to offer high-quality bioactive metabolites like abierixin, milbemycin α1, lasalocid, and tylosin in large-sale, to accelerate your research and manufacturing.
Fermented Bioactive Metabolites for Animal Health
In recent years, the world of animal health has witnessed a significant shift towards the utilization of fermented bioactive metabolites - bioactive chemicals derived from the process of fermentation. This emerging approach holds immense promise in improving the well-being of animals, both in the livestock and companion animal sectors.
Fermentation is a metabolic process involving the conversion of organic compounds, such as carbohydrates, into simpler substances through the action of microorganisms, including bacteria, yeast, and fungi. This ancient method has been used in various industries, including food and medicine. Fermentation has gained recognition for its ability to produce bioactive metabolites - specialized compounds that offer valuable benefits to living organisms. These bioactive metabolites encompass a range of substances, including organic acids, peptides, enzymes, antibiotics, and vitamins, which can have profound implications for animal health.
Applications of Fermented Bioactive Metabolites in Animal Health
- Gut Health and Digestion
Fermented bioactive metabolites have shown remarkable potential in promoting gut health and optimizing digestion in animals. These metabolites, although not directly used as animal feed, can be incorporated into dietary supplements to enhance nutrient absorption and utilization. By creating a favorable environment in the gastrointestinal tract, they help in inhibiting harmful pathogens while promoting the growth of beneficial gut bacteria. This balanced gut microbiota is pivotal for efficient digestion, nutrient absorption, and overall animal health.
- Immune System Support
Bioactive metabolites derived from fermentation can play a vital role in bolstering the immune systems of animals. These metabolites, when appropriately formulated into supplements or veterinary medicines, have the ability to stimulate the production of antibodies and enhance immune cell activity. This proactive immune support helps animals mount a robust defense against infections and diseases, ultimately reducing the frequency and severity of illnesses.
- Nutrient Enrichment
Although not directly fed to animals, fermented bioactive metabolites have the potential to enrich animal feed indirectly. By enhancing the nutrient content of animal feed through the fermentation of specific components, these metabolites can ensure that animals receive a more balanced and nutrient-rich diet. This is particularly advantageous in regions where animal feed may lack essential nutrients, leading to improved growth and health in animals.
Advantages of Fermented Bioactive Metabolites in Animal Health
While our bioactive chemicals are not directly administered to animals, they offer several advantages to our customers involved in the animal health industry:
- Innovation in Product Development
Companies in the animal health sector can leverage fermented bioactive metabolites to develop innovative dietary supplements and veterinary medicines. These products can address specific health challenges in animals, ultimately improving their well-being and longevity.
- Products Differentiation
The incorporation of fermented bioactive metabolites into animal health products sets companies apart in a competitive market. Consumers are increasingly seeking natural and sustainable solutions for their animals, and these bioactive metabolites align with those preferences.
- Sustainable and Responsible Practices
Utilizing fermented bioactive metabolites promotes sustainable and responsible agricultural practices. By reducing the reliance on synthetic chemicals and antibiotics, these metabolites contribute to a more environmentally friendly approach to animal healthcare.