Antibiotics

Antibiotics

Catalog Product Name / CAS / Description Structure
BBF-00693

Ansamitocin P-3 (66584-72-3)

Inquiry

It is produced by the strain of Nocardia sp. C-15003(N-1). It has the function of anti-tumor, anti-plant pathogenic fungi, skin fungi and protozoa, and has no antibacterial activity.

BBF-04306

A minor polar analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis. It is the common degradation product of teicoplanins A2-1 to 5, resulting from cleavage of the lipoaminoglycoside substituents.

BBF-03496

Teichomycin A2-5 is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria.

BBF-04305

An analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis.

BBF-04304

A major analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis.

BBF-03494

Teicoplanin A2-1 is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria.

BBF-02559

Mitomycin C (50-07-7)

Inquiry

Mitomycin C is a quinone mitomycin antibiotic produced by Str. caespitosus NRRL 2564. It has antibacterial, antimycobacterial and antiviral activities. And it has an inhibitory effect on tumors.

BBF-04081

Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.

BBF-01877

Illudin S (1149-99-1)

Inquiry

Illudin S is a natural sesquiterpene agent with strong anti-tumour activity. Illudin S inhibits DNA synthesis via an unknown mechanism.

BBF-03888

Sulopenem (120788-07-0)

Inquiry

Sulopenem is a penem antibiotic and a β-lactamase inhibitor produced by Penicillium. Sulopenem showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia.

BBF-03862

Cefozopran hydrochloride is a fourth-generation cephalosporin produced by Cephalosporium.

BBF-01851

Fumagillin (23110-15-8)

Inquiry

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an anti-infective and antiangiogenic agent.

BBF-04632

Meropenem Trihydrate is a carbapenem antibiotic, which has broad spectrum antibacterial activity.

BBF-05702

Rezafungin (1396640-59-7)

Inquiry

Rezafungin, a next-generation, broad-spectrum and long-lasting echinocandin, has potent antifungal activity against Candida spp., Aspergillus spp. and Pneumocystis spp..

BBF-04568

Tobramycin (32986-56-4)

Inquiry

Tobramycin is an aminoglycoside antibiotic with an IC50 of 9.7 μM.

BBF-01806

Griseofulvin (126-07-8)

Inquiry

It is produced by the strain of Penicillum griseofulvum. It can inhibit the strains of ClassZygomycetes, Ascomycetes and Deuteromycetes (MIC is 1-20 μg/mL), It can also inhibit the crimping of the spore tube of garlic rot grape (MIC is 1 μg/mL). It has obvious inhibitory effect on metaphase mitosis of bone marrow, small intestine and Walker 256 cancer cells.

BBF-04526

FR-901464 (146478-72-0)

Inquiry

It is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.

BBF-01827

Deoxymulundocandin is an echinocandin antifungal agent isolated from Aspergillus sydowii.

BBF-04445

A major analogue of the family of lipoglycopeptide antibiotics produced by actinoplanes teichomyceticus. It possesses potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis.

BBF-04146

Aureobasidin A (127785-64-2)

Inquiry

Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase.

BOC Sciences has been committed to providing customers with high quality antibiotics at the best price.

Antibiotics refer to secondary metabolites generated by fungi, bacteria or other microorganisms in the course of life that have anti-pathogen or other activities. Antibiotics are drugs that can inhibit or kill other microorganisms (bacteria/fungi/virus/parasites, etc.) at low concentrations. They have low toxicity, high safety, and can be directly applied to the human body.

Classification of Antibiotics

The method of manufacturing antibiotics varies according to the type of antibiotics. Antibiotics are generally extracted from the culture fluid of microorganisms or manufactured by synthetic or semi-synthetic methods.

The classifications are as follows:

1. Antibacterial antibiotics

Depending on the chemical structure, anti-bacterial antibiotics include:

  • β-lactams: penicillins (such as amoxicillin), cephalosporins (such as cefradine), carbapenems (such as imipenem), monocyclic β-lactams (such as aztreonam), Β-lactamase inhibitors (such as sulbactam), etc.
  • Aminoglycosides: including tobramycin, gentamicin, streptomycin, etc.
  • Tetracyclines: including oxytetracycline, chlortetracycline, etc.
  • Macrolides: Including erythromycin, clarithromycin, middynecin, etc.
  • Chloramphenicol: including chloramphenicol, thiamphenicol, etc.
  • Lincomycins: including lincomycin, clindamycin, etc.
  • Other antibacterial antibiotics: such as vancomycin, polymyxin, rifampin.

2. Antifungal antibiotics: including griseofulvin, amphotericin B, etc.

3. Antituberculosis antibiotics

4. Anti-tumor antibiotics: including mitomycin, actinomycin D, bleomycin, etc.

5. Immunosuppressive antibiotics: such as cyclosporine.

In addition, according to the scope of antibacterial (antibacterial spectrum), antibiotics can be divided into broad-spectrum antibiotics and narrow-spectrum antibiotics. Broad-spectrum antibiotics have inhibitory effects on most G+ bacteria, G- bacteria, certain chlamydia, mycoplasma and protozoa, such as tetracyclines and chloramphenicols. Narrow-spectrum antibiotics merely have antibacterial effects on a single species or genus of bacteria.

Reaction Mechanism of Antibiotics

Different antibiotics have different mechanisms of action on microorganisms. Generally speaking, antibiotics mainly have three mechanisms of action: inhibit the synthesis of cell walls, inhibit the synthesis of proteins, and inhibit the replication of genetic information.

Application of Antibiotics

Antibiotics can control more than 95% of diseases caused by bacterial infections. Therefore, antibiotics are extensively used in the prevention and treatment of poultry, livestock, crops and other diseases, and have now become the main drugs for the treatment of infectious diseases. In addition to anti-bacterial infection treatment, antibiotics can also be used for anti-fungal, anti-tumor and immunosuppressive aspects. In addition, antibiotics are also used in food preservation, such as tetracycline used in meat preservation.

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