Antibiotics

Rhodomycin are a family of antibiotics produced by a red-pigmented mutant of Streptomyces griseus. They possess anti-gram-positive bacteria, anti-gram-negative bacteria and antifungal properties.

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, which is used as an antiparasitic drug for the treatment of certain parasitic roundworm infections. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection. Ivermectin is a mixture of mostly Ivermectin B1a (>80%) with some Ivermectin B1b (<20%), which are macrolides from Streptomyces avermitilis.

Prodigiosin is an antibiotic from Serratia marcescens and other bacteria. It has a wide range of biological activities, including antimalarial, antifungal, anticancer and immunosuppressant properties.

It is a basic cytotoxic polypeptide produced by the strain of Streptomyces netropsis. It is a DNA minor groove binding ligand.

Neomycin B Sulfate is the sulfate salt form of Neomycin B, an aminoglycoside antibiotic.

Aurantimycin A is an antibiotic isolated from Streptomyces aurantiacus IMET 43917. Aurantimycin A has activity against Gram-positive bacteria and inhibits cell adhesion.

Oritavancin is a glycopeptide antibiotic used in the treatment of skin infections. It has a role as an antibacterial drug and an antimicrobial agent.

Tylvalosin, a macrolide antibiotic, is active against S. aureus, E. coli, and P. multocidas with MICs of 2, 128, and 128 μg/mL, respectively. Tylvalosin (5 and 10 μg/mL) reduces LPS-induced production of proinflammatory cytokines, prostaglandin E2 (PGE2) and nitric oxide in RAW 264.7 cells. Preparations containing tylvalosin have been used for the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.

Meropenem, a carbapenem antibiotic with a broad spectrum of activity, can be administered intravenously and is used for severe bacterial infections caused by sensitive agents. Meropenem inhibits cell wall synthesis in Gram-positive and Gram-negative bacteria. Meropenem has obvious inhibitory effect on aerobes and anaerobes including Klebsiella, E. coli, Enterococcus, Clostridium sp..

Puromycin hydrochloride is the hydrochloride salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger. It is an anti-trypanosomiasis drug with antibiotic activity.

Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections.

Neomycin sulfate is an aminoglycoside antibiotic. It can be used to prevent and treat gastrointestinal infections caused by gram-negative bacteria such as Salmonella and Escherichia coli, such as Salmonella infection in pigs and chickens, E. coli disease, chicken paratyphoid, staphylococcal disease, necrotizing enteritis, fowl cholera, etc.

Spectinomycin sulfate is an aminocyclitol aminoglycoside antibiotic produced by Streptomyces spectabilis with bacteriostatic activity. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Triclosan is a broad-spectrum antibacterial and antifungal agent added in consumer products such as toothpaste, soaps, detergents, etc.

Furazolidone is an antimicrobial agent used for the treatment of bacterial and protozoal infections.

Dichlorophen is an antimicrobial agent with activity against cestodes, protozoa, fungi, and bacteria.

Oxolinic acid is an inhibitor of the enzyme DNA gyrase and DNA synthesis.

Carbadox is a broad-spectrum antimicrobial agent.

Ceftolozane TFA salt is the salt of Ceftolozane, which is the fifth-generation cephalosporin antibiotic. It is a semi-synthetic β-lactam antibiotic used to treat Gram-negative or Gram-positive bacterial infections that have developed resistance to conventional antibiotics.

Zerbaxa (Ceftolozane/tazobactam), a combination product consisting of a cephalosporin-class antibacterial drug and a beta-lactamase inhibitor, is a combination antibiotic medication used for the treatment of complicated urinary tract infections and complicated intra-abdominal infections in adults.