Antibiotics

Penicolinate A is a metabolite produced by Penicillium species, displaying antimalarial and antituberculosis activity. It exhibits potent cytotoxic activity against the human ovarian cancer cell line A2780 with an IC50 value of 4.1μM.

Meclocycline is a tetracycline antibiotic derived from methacycline. It has a broad-spectrum antibacterial and antiprotozoan activity.

Siamycin I is a tricyclic peptide antibiotic originally isolated from Streptomyces sp. AA6532. It exhibits antiviral and antibacterial effects against HIV and HSV, as well as B. subtilis, M. luteus and S. aureus.

It is produced by the strain of Streptomyces sp. NK26588. Iromycin A is a bacterial pyridone metabolite that acts as a nitric oxide synthase (NOS) inhibitor with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS).

It is an antibiotic produced by Streptomyces and Bacillus that can inhibit cell wall synthesis in plant-pathogenic oomycetes and certain fungi as well as some bacterial species.

Nargenicin A1 is a macrolide antibiotic produced by Nocardia sp. that is effective against Gram-positive bacteria including taphylococcus and Clostridia. It shows more potent efficacy against methicilin resistant S. aureus (MRSA) than erythromycin and vancomycin.

Spirolaxine is a long-chain phthalide antibiotic produced by Sporotrichum laxum. It exhibits anti-Helicobacter pylori property.

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma sp. It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 µg/ml, respectively). Antibiotic PF 1052 inhibits neutrophil migration in a wound assay and reduces pseudopodia formation.

Ambuic acid is a cyclohexanone originally isolated from Pestalotiopsis and Monochaetia species. Antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. It is active against P. ultimum (MIC = 7.5 µg/ml) and inhibits the growth of a variety of other phytopathogenic fungi. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP).

It is a class III antibiotic isolated from Amycolatopsis lurida originally used in the treatment staphylococcal infections. However, it has side effects like thrombocytopenia and platelet agglutination.

Sulfadiazine is a sulfonamide antibiotic. It has activity against both Gram-positive and Gram-negative bacteria.

Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes. It acts as an antagonist of neurokinin-1 (NK1) receptor.

A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis. It has activity against Gram-positive bacteria and many strains of anaerobic bacteria.

Tropodithietic acid (TDA) is a broad-spectrum antibiotic produced by the marine bacterium Roseobacter gallaeciensis. It is effective against a variety of Gram-negative α-proteobacteria, γ-proteobacteria, and flavobacteria as well as Gram-positive actinobacteria strains in a disc assay.

A second generation fluoroquinolone antibiotic.

Ceftazidime is a third generation cephalosporin antibiotic useful for the treatment of bacterial infections. It can be used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, pseudomonas aeruginosa infection and vibrio infection.

Ofloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic. It has antimicrobial activity. It can inhibit DNA gyrase, Topo II (topoisomerase II) and Topo IV (Topo II α).

Cefuroxime sodium is a second-generation cephalosporin antibiotic resistant to beta-lactamase. It has a broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria.

Cephalothin sodium is a semisynthetic first generation cephalosporin antibiotic having a broad spectrum of antibacterial activity that is administered parenterally used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or join. It is active against gram-positive and gram-negative bacteria.

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. It is active against a variety of Gram-positive and Gram-negative bacteria in vitro, including S. aureus, L. monocytogenes, P. aeruginosa, Legionella, N. gonorrhoeae and H. pylori.