Antibiotics

Apicidin is a cyclic peptide antibiotic with broad-spectrum antiproliferative, antiparasitic and antiprotozoan activity. It is a histone deacetylase (HDAC) inhibitor with anti-angiogenesis and apoptosis-inducing effects.

Chrysomycin A is a C-glycoside antitumor antibiotic isolated from Streptomyces, and it is an inhibitor of the catalytic activity of human topoisomerase II. It has effective antibacterial, antifungal, antiviral and antitumor activities. It may act as a light-activated cross-linking agent between DNA and histones.

Cefpodoxime sodium is a third generation cephalosporin beta-lactam antibiotic. Activity against Gram-positive and Gram-negative bacteria.

Puromycin dihydrochloride is the hydrochloride salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger. It is an anti-trypanosomiasis drug with antibiotic activity.

Bacitracin F is a major Bacitracin analog, a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI). It is isolated from Bacillus.

Sordarin is an antifungal metabolite produced by Sordaria areneosa. It inhibits protein synthesis via stabilizing the ribosome/EF2 complex.

Cefbuperazone is a third-generation cephalosporin antibiotic.

An antibiotic in the streptothricin class of antibiotics.

Arbekacin is a semi-synthetic aminoglycoside antibiotic used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

Magainin II is a broad-spectrum antibiotic isolated from Xenopus laevis. It has anti-fungal and anti-cancer activity in vitro.

Cotrimoxazole is a fixed antibiotic composed of trimethoprim and sulfamethoxazole. It blocks the synthesis of nucleotides to inhibit cellular metabolism in bacteria.

Ristocetin sulfate is a potent antibacterial glycopeptide antibiotic produced by Amycolatopsis lurida, which was withdrawn from clinical use following a high incidence of thrombocytopenia.

Celastramycin A is a bioactive compound isolated from endophytic bacteria. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria. It inhibits the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC). Celastramycin A suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α with IC50 of 0.01 μg/ml. It can also be used as a lead compound for novel immunosuppressive agents.

Eravacycline, also known as TP-434, a novel antibiotic. Eravacycline showed potent broad-spectrum activity against 90% of the isolates (MIC90) in each panel at concentrations ranging from 0.008 to 2 μg/ml for all species panels except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 values of 32 μg/ml for both organisms).

Alamethicin, an antibiotic peptide compound, could be obtained from the fungus Trichoderma viride and is commonly used in studing ion channel assembly and peptide-membrane interactions.

Cephapirin benzathine is a first-generation cephalosporin with a broad spectrum of activity against gram-positive and gram-negative organisms. Its resistance to β-lactamase is higher than that of the penicillin family. commonly used in the veterinary field.

An unusual anthracycline produced by streptomyces nogalater var. Nogalater. It is a potent antibacterial and antitumor agent that interacts with DNA by intercalation.

Ristocetin A is a potent antibacterial glycopeptide antibiotic. It induced platelet aggregation by binding to a factor absent in people suffering from von willebrands disease, and is an important diagnostic acid.

Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide. It is a broad spectrum antibiotic with good activity against gram-negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.

Ramoplanin complex is a complex of three high molecular weight glycolipopeptide peptides, the chain length and the shape of the diketene lipid side chain are different. It inhibits cell wall biosynthesis through a mechanism different from vancomycin-related glycopeptide.