Antibiotics

MM 47755 is produced by the strain of greysporing streptomycete. It has anti-Gram-negative bacteria and fungi activity (100μg/ mL).

UK 78624 is a melbemycin antibiotic produced by Streptomyces hygroscopicus. It possesses anthelmintic and ectoparasiticidal activity.

Asterobactin is a siderophore antibiotic produced by Nocardia asteroides IFM 0959. It has anti-tumor activity and inhibits HL-60 and HeLa cells at a concentration of 0.2-3.2 μg/mL, and Fe3+ can reduce its activity.

7-Demethoxy-7-amino-9a-O-methylmitomycin is a mito-mycin antibiotic produced by Streptomyces caespitosus. It has anti-tumor and gram-positive bacteria activity.

Mitomycin D is a mito-mycin antibiotic produced by Streptomyces caespitosus with anti-tumor activity. It is also a semi-synthetic antibiotic with anti-leukemic properties.

7-O-DemethyIcelesticetin is a lincomycin antibiotic produced by Streptomyces celestis.

3''-N-demethyl gentamicin C1a is an aminoglycoside antibiotic produced by Micromonospora sagamiensis G-665.

Olivanic acid is a β-lactam antibiotic produced by Str. olivaceus. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase.

Reblastatin is an Ansa antibiotic produced by Streptomyces hygroscopicus subsp. hygroscopicus SANK 61995 and is a reduction product of Geldanamycin. It is a cell cycle inhibitor that can inhibit cell proliferation. The IC50 for human mesenchymal lymphoma U-93 is 0.43 μg/mL, and the reference geldanamycin is 0.0011 μg/mL.

Roseoferin A1 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity.

Roseoferin C2 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity.

CV-1 is an antibiotic produced by Streptomyces sp. CO-1. It has anti-Escherichia coli activity in combination with spiramycin, and its mechanism is to inhibit lipopolysaccharide synthesis.

DK-7814 is a quinone antibiotic produced by Dactylosporangium purpureum R1-1. Activity against gram-positive bacteria.

LL-E19085alph is a quinone antibiotic produced by Micromonospora citrea. It is active against gram-positive bacteria.

2-(3-Alanyl)clavam is produced by the strain of Streptomyces clavuligerus. It has activity against gram-positive bacteria and yeast, and its activities can be antagonized by D or L methionine, L-cysteine threonine, L-homocysteine and O-acetyl-L-high serine.

It is produced by the strain of Marasmius alliaceus (Basidiomycetes). It inhibits the activity of Ehrlician ascites cancer cells.

It is produced by the strain of Streptomyces venezuelae Tu 2460. Mainly resistant to gram-negative bacteria, the biotin vitamins can offset its activity.

It is produced by the strain of Emericellopsis microspora. It mainly has activity against gram-positive bacteria and various protozoa. The activity of Emerimicin II is stronger than the Emerimicin III and IV.

It is produced by the strain of Emericellopsis microspora. It mainly has activity against gram-positive bacteria and various protozoa. The activity of Emerimicin II is stronger than the Emerimicin III and IV.

It is produced by the strain of Trichoderma harzianum OUPS-N115. Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED50 of > 100 μg/mL.