Antibiotics

FL-120C' is produced by the strain of Streptomyces chattanoogensis subsp. taitungessis. It has anti-Gram-positive aerobes and anaerobe activity.

FL-120D' is produced by the strain of Streptomyces chattanoogensis subsp. taitungessis. It has anti-Gram-positive aerobes and anaerobe activity.

It is originally isolated from Nocardia uniformis subsp. tsuyamanensis. FR-29038 has anti-Bacillus, Escherichia, Klebsiella, Pseudomonas, Salmonella, Shigella and other family bacteria activities.

FR 32863 is produced by the strain of Streptomyces lavendulae 8006. FR 32863 has anti-gram-positive and anti-gram-negative activities.

FR-33289 is produced by the strain of Streptomyces rubellomurinus subsp. indigoferus 24. FR-33289 has anti-gram-positive and anti-gram-negative activities.

FR 65814 is originally isolated from Penicillum jensenii F-2883. It has a strong immunosuppressive effect, and the IC50 of inhibiting mixed lymphocyte reaction (MLR) in mice is 34 nmol/L.

FR 66979 is produced by the strain of Streptomyces sandaensis No. 6897. It has inhibitory activity against tumor cells, including leukemia P388 cells and melanoma B16 cells.

FR-182877 is produced by the strain of Streptomyces sp. No. 9885. It has a strong effect on rat ascites and solid tumors in vivo, and has no antibacterial activity.

It is a polyphenolic compound with anti-influenza A virus effect.

FR 252921 is produced by the strain of Pseudomonas fluorenscens No. 408813. It shows immunosuppressive effect in mice in vivo and in vitro, and has synergistic effect with FK-506.

FR-252922 is produced by the strain of Pseudomonas fluorenscens No. 408813. It shows immunosuppressive effect in mice in vivo and in vitro, and has synergistic effect with FK-506.

It is produced by the strain of Streptomyces prunicolor. FR 900109 has anti-gram-positive bacteria activity.

FR 900130, isolated from Streptomyces catenulae, is an antibiotic easily to decompose. It has anti-gram-positive and anti-gram-negative activities, and has a synergistic effect with D-cycloserine.

FR 900137 is produced by the strain of Streptomyces unzenensis 2050. It has a broad spectrum of antibacterial activity and has a strong effect on Pseudomonas aeruginosa Ⅳ.

It is originally isolated from Streptomyces xanthocidicus 301. FR-900148 can inhibit gram-positive and gram-negative bacteria, but has no effect on pseudomonas aeruginosa.

FR 900403 is a nucleoside antibiotic originally isolated from Kernia sp. F-19849. It had anti-Candida activity, and the MIC against Candida albicans FP663 was 0.4 μg/mL.

FR 900482 is produced by the strain of Streptomyces sandaensis No. 6897. It is highly sensitive to Bacillus stearothermophilus var. calidolactis C 953 and has anti-P388, B16, EL4, FM3A, L1210, BHK-21 and other cell activities.

FR 900523, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 1.6 nM for mouse mixed lymphocyte.

It is produced by the strain of Streptoverticillium fervens. Jawsamycin had strong anti-filamentous fungal activity, and the MIC of Aspergillus Niger, Aureobasidium and Mucor was 0.05 μg/mL.

FR901459, a product of the fungus Stachybotrys chartarum No. 19392, is a derivative of cyclosporin A (CsA) and a powerful immunosuppressant that binds cyclophilin. Its immunosuppressive effect was lower than that of cyclostatin A.