Antibiotics

L-threo-β-Hydroxyaspartic acid is an amino acid antibiotic produced by Arthrinium phaeospermum T-53 and Streptomyces sp. 7540-MC1. It has the activity of inhibiting Bacillus subtilis, Xanthomonas oryzae, Mycobacterium phlei and Botrytis cinerea.

Polymyxin M is a cyclic peptide antibiotic produced by Bacillus polymyxa var. Ross.

APHE-3 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. APHE-3 can also inhibit lymphocyte proliferation in the presence of Phytohemagglutinin, with IC50 of about 0.1 mmol/L.

2-(acetylamino)benzenecarboxamide is an antifungal antibiotic isolated from Streptomyces aurantiogriseus NPO-101.

OM-173αA is a quinone bacterial metabolite originally isolated from Streptomyces hebeiensis, displaying antimicrobial activity. It selectively inhibits Dnmt3b and induces antiproliferative effects in different tumor cell lines. It is effective against Gram-positive bacteria, mycobacterium, yeast and fungus.

OM-173βA is a quinone bacterial metabolite originally isolated from Streptomyces hebeiensis, displaying antimicrobial activity. It is effective against mycoplasma and fungus.

(2S)-2-Amino-2-(1-methylcyclopropyl)acetic acid hydrochloride is an amino acid antibiotic produced by Micromonospora miyakonensis PA-4046. It has activity against Escherichia coli.

PC-766B is a 16-membered macrolide antibiotic produced by nocardia brasiliensis. It is active against gram-positive bacteria, and some fungi and yeasts, but is inactive against gram-negative bacteria. It shows antitumor activity against murine tumor cells in vitro and in vivo, and weak inhibitory activity against na/K-atpase in vitro.

PD-116152 is a novel and highly substituted phenazine. It has antitumor activity. It was isolated from the culture broth of a Streptomyces sp.

PD-116779 is a novle antitumor antibiotic belonging the benz[a]anthraquinone class.

PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans.

PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans.

Sch-37137 is a dipeptide antibiotic produced by Micromonospora sp. SCC 1792. It was weakly active against species of Candida and dermatophytes (mean MICs greater than or equal to 128 mg/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs greater than or equal to 12 mg/ml) and dermatophytes (mean MICs greater than or equal to 0.8 mg/ml) significantly improved in MA medium.

Sch-38519 is an isochromanequinone structurally related to lactoquinomycin. It is isolated from Thermomonospora sp. SCC 1793. It inhibits thrombin-induced aggregation of human platelets and is active against gram-positive and gram-negative bacteria.

It is an apoptosis inducer originally isolated from Streptomyces rochei 3218-GM-2. FE35A was cytotoxic to U937 leukemia cells with IC50 of 3.7 nmol/L.

It is an apoptosis inducer originally isolated from Streptomyces rochei 3218-GM-2. FE35B was cytotoxic to U937 leukemia cells with IC50 of 4.6 nmol/L.

It is produced by the strain of Streptomyces griseosporeus. FK 409 has the function of releasing nitric oxide, dilating blood vessels and inhibiting platelet aggregation.

FL-120A is produced by the strain of Streptomyces chattanoogensis subsp. taitungessis. It has anti-Gram-positive aerobes and anaerobe activity.

FL-120B is produced by the strain of Streptomyces chattanoogensis subsp. taitungessis. It has anti-Gram-positive aerobes and anaerobe activity.

FL-120C is produced by the strain of Streptomyces chattanoogensis subsp. taitungessis. It has anti-Gram-positive aerobes and anaerobe activity.