Antibiotics

It is produced by the strain of Str. fradiae NRRL-3417, Str. viridchromogenes NRRL-3413. It's an antibiotic that contains phosphorus. It has anti-gram positive bacterial and negative bacterial activity, inorganic phosphorus and sodium chloride can reduce its activity. It has protective effect on mice infected with Staphylococcus aureus, Salmonella typhi and Salmonella paratyphi B by oral administration.

It is an antibiotic produced by the strain of Actinomadura verrucosospora Q886-2. It has weak antimicrobial effect and can prolong the survival time of mice transplanted with melanoma. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D.

It is a nitrogenous heterocyclic indole antibiotic produced by the strain of Chromobacterium violaceum. It has anti-gram-positive bacteria, fungi and protozoa effects. The serum has an effect on its activity.

It is a peptide antibiotic produced by the strain of Str. puniceus 1314-5 and Str. floridae A5014. It has broad-spectrum antibacterial and strong anti-mycobacterium effect. 1-10 μg/mL of Viomycin can inhibit the growth of most tuberculosis bacilli, the main effect is to inhibit the protein synthesis of bacteria, but bacteria are prone to develop drug resistance. In clinical application, it is only used as a second-line drug to treat tuberculosis.

It is produced by the strain of Str. nitrosporeus AM-2722. It has antiviral effect. It inhibits four RNA viruses and four DNA viruses with MIC (μg/mL) of 0.008-0.04 and 0.005-0.03, respectively. It has weak antifungal effect.

It is a depsipeptide antibiotic produced by the strain of Str. virginiae and Str. virginiae var. sp. It has anti-gram-positive bacteria and mycobacterium effects, and the antibacterial activity of component M of Virginiamycin against cocci is stronger than component S, while the activity is stronger than component M.

It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation.

It is a nitrogenous heterocyclic antibiotic produced by the strain of Str. sp. and Pseudomonas cocovenenans. It has anti-bacterial and mycobacterium effects.

It is a cyclic peptide antibiotic produced by the strain of Streptomyces sp. K96-0670. It has anti-Xanthomonas oryzae, Acholeplasma laidlawii, Piricularia oryzae and Staphylococcus aureus activity, but no effect on other bacteria and fungi.

It is produced by the strain of Noracdia sp. 2-200. It has anti-gram-negative bacteria and anaerobe activity.

It is produced by the strain of Streptomuces aureofaciens var. 38-2-14. It shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

Demecycline is a tetracycline antibiotic produced by the strain of Streptomyces aureofaciens var. 38-2-14 that is a C6-demethylated derivative of tetracycline and is used to treat bacterial infections including pneumonia and other respiratory tract infections.

It is produced by the strain of Amycolata autotrophica. It has anti-gram-positive bacteria (MIC is 0.04-0.12 μg/mL) and weak anti-Saccharomyces cerevisiae (MIC is 100 μg/mL) activity.

It is a β-lactone antibiotic produced by the strain of Cephalosporium sp. It has a strong inhibitory effect on hydroxymethyl glutaryl coenzyme A (HMG-CoA) synthase.

It is an antitumor antibiotic produced by the strain of Streptomyces SA 3097. It is an effective inhibitor of protein synthesis and plant growth regulator.

It is a polyene antibiotic produced by the strain of Streptomyces lavendulae MA-4758. It has the activity of anti-gram-positive bacteria and gram-negative bacteria, and is an animal growth promoter.

It is a nucleoside antibiotic produced by the strain of Streptomyces griseolus (NRRL 3739). It has the effect against plant pathogenic fungi, candida, Pasteur's yeast and trypanosome. It mainly has the effect against fungal, especially has the strong effect to the Yeast. LD50 is greater than 400 mg/kg.

Steffimycin is an anthracycline antibiotic produced by Str. steffisburgensis var. steffisburgensis NRRL 3193. Activity against Gram-positive bacteria and fungi.

Steffimycin B is an anthracycline antibiotic produced by Str. steffisburgensis var. steffisburgensis NRRL 3193. Activity against gram-positive bacteria.

Streptolydigin is a nitrogen-containing and oxygen-containing heterocyclic antibiotic produced by Str. lydicus NRRL 2433. It has anti-gram-positive bacteria and mycobacterial activity.