Antibiotics

It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells.

It is produced by the strain of Fusarium sp. AB 2202 W-161. It has weak antifungal activity. Sorbitol can offset its antifungal activity. It inhibits glucan synthase with ID50 of 242.0 μg/mL.

It is a cyclopentane derivative of antibiotic produced by the strain of Str. erythrochromogenes W-115-C. It has anti-bacterial effect, but the effect is weak. Serum and cysteine can reduce its antibacterial activity. It can inhibit HeLa cells and Eichler ascites cancer cells in vitro.

It is produced by the strain of Str. violaceoruber sp. JA 2861. It has anti-gram-positive bacteria effect, but no anti-gram-negative bacteria, fungi and yeast effects.

It is produced by the strain of Marasmius scorodonius. It has anti-bacterial, Streptomyces and fungal effects. In vitro it inhibits DNA-dependent RNA polymerases with IC50 of 25 μg/mL.

It is a terpenoid antibiotic produced by the strain of Scytalidium sp. FSC-470. It has antifungal effect. The antibacterial activity is strongest when the pH value of liquid determination is 3.5, and the activity decreases when the pH value increases.

It is an anthraquinone antibiotic produced by the strain of Streptomyces sp. GW 19/1251. It has moderate activity against Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria such as Escherichia coli and green Streptomyces chlorophyllus.

Seldomycin 1 is an aminoglycoside antibiotic produced by the strain of Str. hofunensis nor. sp.. It has a broad spectrum of antimicrobial activity, and Seldomycin F5 has the strongest antimicrobial activity. It is cross-resistant to E. coli with aminoglycoside antibiotic passivation enzyme (such as APH (3')-Ⅰ, APH(3')-II, AAC(6'), AAC(2)). ED50 is greater than 1000 mg/kg (abdominal infection in mice, intravenous administration).

Seldomycin 2 is an aminoglycoside antibiotic produced by the strain of Str. hofunensis nor. sp.. It has a broad spectrum of antimicrobial activity, and Seldomycin F5 has the strongest antimicrobial activity. It is cross-resistant to E. coli with aminoglycoside antibiotic passivation enzyme (such as APH (3')-Ⅰ, APH(3')-II, AAC(6'), AAC(2)). ED50 is 36-60 mg/kg (abdominal infection in mice, intravenous administration).

Seldomycin 3 is an aminoglycoside antibiotic produced by the strain of Str. hofunensis nor. sp.. It has a broad spectrum of antimicrobial activity, and Seldomycin F5 has the strongest antimicrobial activity. It is cross-resistant to E. coli with aminoglycoside antibiotic passivation enzyme (such as APH (3')-Ⅰ, APH(3')-II, AAC(6'), AAC(2)).

Seldomycin 5 is an aminoglycoside antibiotic produced by the strain of Str. hofunensis nor. sp.. It has a broad spectrum of antimicrobial activity, and Seldomycin F5 has the strongest antimicrobial activity. It is cross-resistant to E. coli with aminoglycoside antibiotic passivation enzyme (such as APH (3')-Ⅰ, APH(3')-II, AAC(6'), AAC(2)). ED50 is 7.5-15 mg/kg (abdominal infection in mice, intravenous administration).

It is produced by the strain of Str. ochrosporus NRRL 3146. It has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, streptomycin, neomycin, macrolide antibiotics. It also has weaker effect of anti-Gram-negative bacteria.

It is produced by the strain of Str. ochrosporus NRRL 3146. It has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, streptomycin, neomycin, macrolide antibiotics. It also has weaker effect of anti-Gram-negative bacteria.

Septacidin is a glycoside antibiotic produced by the strain of Str. fimbriatus. It has anti-fungal effect. It inhibits L cells (NCTC 929) with ED50 of 25 ng/mL. It can inhibit sarcoma-180 and adenocarcinoma 755 cells in vivo.

It is a polyether antibiotic produced by the strain of Str. hygroscopicus NRRL 5678. It has anti-bacterial effect and is also effective against some drug-resistant bacteria (Resistance to penicillin, aminoglycoside antibiotics, etc).

It is a polyether antibiotic produced by the strain of Str. hygroscopicus NRRL 5678. It has anti-bacterial effect and is also effective against some drug-resistant bacteria (Resistance to penicillin, aminoglycoside antibiotics, etc).

It is a depsipeptide antibiotic produced by the strain of Serratia marcescens HY-3. It has anti-gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak.

It is a macrolide antibiotic produced by the strain of Str. flavochromogenes R-903. It has anti-gram-positive bacteria and mycoplasma activity, and has no cross-resistance with erythromycin and mycomycin.

It is produced by the strain of Str. hygroscopicus A1491. It has anti-gram-positive bacteria and fungi effects.

It is produced by the strain of Str. hygroscopicus A1491. It has anti-gram-positive bacteria and fungi effects.