Antibiotics

Variamycin is a glycoside antibiotic originally isolated from Streptomyces olivovariabilis 6604-9. It has the effect of resisting gram-positive bacteria, fungi and tumors.

It is produced by the strain of Micromonospora grisea. Verdamycin has anti-bacterial effect. In in vivo test of mice, it has protective effect on the infection of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus.

Vermiculine is produced by the strain of Pen. vermiculatum CCM-F-2. It has anti-protozoal and anti-tumor effects, and it also has a less potent effect against gram-positive bacteria.

Vernamycin B is originally isolated from Str. loidensis. Vernamycin B has an antimicrobial effect, but is less effective against gram-negative bacteria and mycobacteria.

It is produced by the strain of Myrothecium verrucaria NRRL 3003. Verrucarin B has an effect on Ascites carcinoma, also has a weak inhibitory effect on fungi.

Verrucarin K is produced by the strain of Myrothecium verrucaria NRRL 3003. The ED50 of Verrucarin K on giant cell tumor P-815 cells was about 0.001 μg/mL.

Versicolin is originally isolated from Asp. versicolor. It only has antibacterial effect on filamentous fungi, and has no inhibitory effect on yeast-like fungi and bacteria.

Versicolorin A is a quinone antibiotic produced by the strain of Asp. versicolor. It has the effect of anti-tuberculosis Mycobacterium H37RV and other mycobacteria.

Versicolorin B is a quinone antibiotic produced by the strain of Asp. versicolor. It has the effect of anti-tuberculosis Mycobacterium H37RV and other mycobacteria.

Verticillin B is originally isolated from Verticillium sp. Tm-759. It has the effect of anti-gram-positive bacteria, mycobacterium and protozoa, and has the inhibitory effect on the cancer of Ascites.

BU-4704 is produced by the strain of Aspergillus sp. No. FA2692. It has anti-gram-positive bacteria, anti-gram-negative bacteria and cryptococcus neoformans activity. The IC50 of human colorectal cancer cells (HCT-16) and murine melanoma were 0.63 and 4.3 μg/mL, respectively.

C-2801X is originally isolated from Streptomyces heteromorphus. It is mainly resistant to Gram-positive bacteria and negative bacteria.

It is produced by the strain of Streptomyces griseus subsp. cryophilus C-19393. C-19393 E5 has anti-gram-positive and anti-gram-negative bacteria activity and strong β-lactamase inhibition.

CB-25-I, a water-soluble dipeptide, is produced by the strain of Serratia plymuthica. It has an inhibitory effect on individual Candida bacteria (Condida albicans M-9, C. guilliermondii IFO 0454).

CC-1065 is originally isolated from Streptomyces zelensis and its bioactivity was very strong. CC-1065 is against gram-positive bacteria with the MIC=1-10 ng/mL, against most gram-negative bacterial and fungi with the MIC of 1 μg/mL.

CGP-9000 is a semisynthetic cephalosporin which has a wide antibacterial spectrum. Its antibacterial activity was similar to that of cefalexin in vitro, but the effect of oral administration was 2-7 times stronger than that of cefalexin and cefradine in mice.

CJ-12371 is a DNA gyrase inhibitor originally isolated from N 983-46. It was resistant to Gram-positive bacteria, including Staphylococcus, Streptococcus, Enterococcus and Ciprofloxacin, with MIC of 25-100 μg/mL.

CJ-12373 is produced by the strain of Penicillum sp. CL22557. It inhibits the superhelix and relaxation mediated by DNA gyrase, not form cracking intermediates, also inhibits the relaxation mediated by eukaryotic topoisomerase II. And it also has anti-Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus agalactiae, which are sensitive and resistant to ciprofloxacin.

It is produced by the strain of Phanerochaete velutina CL6387. CJ-12954 has strong anti-helicobacter pylori activity.

It is produced by the strain of Phanerochaete velutina CL6387. CJ-13014 is stereoisomer with CJ-12954 and it has strong anti-helicobacter pylori activity.