Antibiotics

Conglobatin is produced by the strain of Streptomyces conglobatus. It has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. It exhibits an IC50 of 0.63 μg/mL in a NFAT-dependant transcription assay. It has no antifungal, bacterial, protozoan and tumor activity.

It is produced by the strain of Corynebacterium KY-4339. It has weak activity against gram-positive bacteria and gram-negative bacteria.

It is produced by the strain of Corynebacterium KY-4339. It has weak activity against gram-positive bacteria and gram-negative bacteria.

It is produced by the strain of Corynebacterium KY-4339. It has weak activity against gram-positive bacteria and gram-negative bacteria.

It is produced by the strain of Corynebacterium KY-4339. It has weak activity against gram-positive bacteria and gram-negative bacteria.

It is produced by the strain of Corynebacterium KY-4339. It has weak activity against gram-positive bacteria and gram-negative bacteria.

Coumemycin A1 is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, IC50 70 μmol/L. It is produced by the strain of Streptomyces rishirensis, Str. spinichromogene and Str. Spinicoumarensis. It has anti-gram positive bacteria, negative bacteria, mycobacterium (weak) activity, cross-resistance with Novobiocin.

It is produced by the strain of Streptomyces cyanoflavus. It has anti-gram positive bacteria, negative bacteria (weak) and mycobacterium (weak) activity. It has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacterial survival.

It is produced by the strain of Streptomyces orchidaceus, Str. lavendulae, Str. roseochromogenes. It can inhibit bacterial alanine racase, D-alanyl-D-alanine synthetase, and interfere with cell wall biosynthesis. Its antibacterial spectrum is wide, and it has activity against gram-positive bacteria, negative bacteria, mycobacterium, rickettsia and amoeba of dysentery. It is now used as a second-line anti-tuberculosis drug.

It is produced by the strain of Erwinia uredovora 821. L-cycloserine is an excitatory amino acid that is effective against Mycobacterium tuberculosis. It has anti-gram-negative bacterial activity.

It is produced by the strain of Streptomyces humidus. Dihydrostreptomycin is an aminoglycoside antibiotic with a bactericidal property. It is used in the treatment of tuberculosis. Its antibacterial activity is similar to Streptomycin, and cross-resistance with Streptomycin.

It is produced by the strain of Aspergillus fumigatus. It has anti-gram-positive bacterial effects.

It is produced by the strain of Streptomyces distallicus NCIB 8936. It has the activity against gram-positive bacterium, mycobacterium, dermatophyte and Trichophyte. It has inhibitory effects on solid tumors such as Epstein-Barr ascites carcinoma, sarcoma 180, Walker 258, oberling-Guerin osteoma, and also inhibits vaccinosis virus, herpes simplex virus, adenovirus, and mouse hepatitis virus in cell culture.

It is produced by the strain of Oxytetracycline or Methacycline. It is regarded as the third generation of tetracycline. It shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Its antibacterial spectrum is similar to Tetracycline, its antibacterial activity is 2-8 times of Tetracycline, its plasma elimination half-life is as long as 18-22h, and it has little effect on renal function.

It is produced by the strain of Oxytetracycline or Methacycline. It is regarded as the third generation of tetracycline. It shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Its antibacterial spectrum is similar to Tetracycline, its antibacterial activity is 2-8 times of Tetracycline, its plasma elimination half-life is as long as 18-22h, and it has little effect on renal function. It can be used for the prevention and treatment of domestic animal respiratory diseases and mixed infection of bacterial diseases when respiratory diseases occur.

It is produced by the strain of Drosophila subatrata. It is mainly anti-gram-positive bacterial activity.

It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has strong antibacterial and antitumor activity. It can inhibit gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis (MIC is less than 0.01 μg/mL), it can also inhibit klebsiella pneumoniae (MIC is 0.032 μg/mL), other bacteria and yeast (MIC is 1-10 μg/mL).

It is produced by the strain of (Pyridamycin) Streptomyces sp. DO-88. It has anti-gram-positive bacteria, gram-negative bacteria and tumor activity.

It is produced by the strain of Streptomyces cinnamomeus. It has activity against gram-positive bacteria, gram-negative bacteria (individual, weak), Mycobacterium and Candida albicans.

It is produced by the strain of Micromonospora chersina sp. M 956-I and M. globosa. Dynemicin A has a strong killing effect on a variety of tumor cells at Pg/mL level. The cyclic enediyne part of enediyne antibiotics is cycled by Bergman to form aromatic diradicals, which quickly seize hydrogen atoms from the DNA skeleton and break the DNA strand, thus killing tumor cells.