Antidiabetic
| Catalog | Product Name / CAS / Description | Structure |
|---|---|---|
| BBF-05867 |
Gliclazide (21187-98-4) Inquiry |
|
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. |
||
| BBF-05868 |
Pioglitazone hydrochloride (112529-15-4) Inquiry |
|
Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor with Kis of 1.7, 11.8 and 32.1 μM for CYP2C8, CYP3A4 and CYP2C9, respectively. It is an agonist of the peroxisome proliferator-activated receptor γ. |
||
| BBF-05866 |
Sitagliptin (486460-32-6) Inquiry |
|
Sitagliptin (MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is used as a hypoglycemic agent to treat type 2 diabetes. |
