Antidiabetic

Antidiabetic

Catalog Product Name / CAS / Description Structure
BBF-05866

Sitagliptin (486460-32-6)

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Sitagliptin (MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is used as a hypoglycemic agent to treat type 2 diabetes.

BBF-05867

Gliclazide (21187-98-4)

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Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

BBF-05868

Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor with Kis of 1.7, 11.8 and 32.1 μM for CYP2C8, CYP3A4 and CYP2C9, respectively. It is an agonist of the peroxisome proliferator-activated receptor γ.

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