Antidiabetic

Based on the industrial fermentation capability, BOC Sciences provides high-quality bioactive metabolites, including antidiabetic compounds. Our complete product portfolio could meet your needs, and contract fermentation services are also available for special fermented bioactive products.

Fermented Bioactive Metabolites as Antidiabetics

Diabetes, a chronic metabolic condition affecting millions worldwide, poses significant challenges to healthcare. Conventional diabetes management often relies on medication and lifestyle changes. However, emerging research has spotlighted the potential of fermented bioactive metabolites as antidiabetic compounds.

Fermentation, a biological process driven by microorganisms such as bacteria and yeast, has been used to transform organic compounds into valuable products. In the context of diabetes management, fermented bioactive metabolites represent a category of compounds produced through fermentation, which exhibit antidiabetic properties. These metabolites offer a natural and potentially effective approach to complement traditional diabetes treatments.

Examples of Fermented Bioactive Metabolites with Antidiabetic Effects

• Gliclazide: Gliclazide is a bioactive compound that plays a crucial role in diabetes management by blocking whole-cell beta-cell ATP-sensitive potassium currents. Gliclazide inhibits the potassium channels, leading to membrane depolarization, calcium influx, and subsequent insulin release. Gliclazide is commonly used as an antidiabetic medication, primarily for type 2 diabetes. By enhancing insulin secretion, it helps control blood sugar levels.
• Pioglitazone Hydrochloride: Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, acts as a potent agonist of the peroxisome proliferator-activated receptor γ (PPARγ). This receptor plays a critical role in regulating genes involved in glucose and lipid metabolism. Pioglitazone hydrochloride is widely used in the treatment of type 2 diabetes.
• Sitagliptin: Sitagliptin, also known as MK 0431, is a potent inhibitor of dipeptidyl peptidase-4 (DPP4). DPP4 is an enzyme that degrades incretin hormones, which stimulate insulin release in response to food intake. By inhibiting DPP4, Sitagliptin prolongs the action of incretins, leading to increased insulin secretion and reduced blood sugar levels. Sitagliptin is a hypoglycemic agent used to treat type 2 diabetes.

Applications of Fermented Bioactive Metabolites with Antidiabetic Effects

Blood Glucose Regulation

One of the primary applications of fermented bioactive metabolites with antidiabetic effects is in the regulation of blood glucose levels. These metabolites can potentially enhance insulin sensitivity and glucose uptake by cells, helping to stabilize blood sugar levels.

Inflammation Reduction

Chronic inflammation is a common feature of diabetes and can exacerbate its complications. Some fermented bioactive metabolites possess anti-inflammatory properties, helping to mitigate the inflammatory response often seen in diabetic patients.

Oxidative Stress Management

Oxidative stress, characterized by an imbalance between antioxidants and harmful free radicals, is a significant concern in diabetes. Fermented bioactive metabolites, such as resveratrol and berberine, are rich in antioxidants. They can counteract oxidative stress and protect cells from damage, reducing the risk of diabetic complications affecting various organs.

Prevention of Diabetic Complications

Fermented bioactive metabolites may play a vital role in preventing or reducing the risk of diabetic complications. By addressing key factors like blood glucose regulation, inflammation, and oxidative stress, these metabolites can help protect vital organs such as the heart, kidneys, and nerves, reducing the likelihood of diabetic complications.

Advantages of Producing Antidiabetic Compounds by Fermentation

• Sustainability: Fermentation is an eco-friendly process that minimizes the environmental impact associated with traditional chemical synthesis methods. It relies on renewable resources, making it a sustainable approach to producing antidiabetic compounds.
• Reduced Side Effects: Fermentation often yields compounds with fewer side effects compared to synthetic drugs.
• Diverse Sources: Fermentation allows for the production of antidiabetic compounds from various organic materials, including plant extracts. This versatility opens doors to a wide range of potential sources for these compounds.