Antifungal
| Catalog | Product Name / CAS / Description | Structure |
|---|---|---|
| BBF-00683 |
Amphotericin B (1397-89-3) Inquiry |
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It is produced by the strain of Streptomyces nodosus. It is an important antifungal drug, especially for deep fungal infection. Liposomes were prepared to reduce toxic and side effects. |
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| BBF-01858 |
Fungichromin (6834-98-6) Inquiry |
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A pentaene antifungal produced by streptomyces; exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols. |
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| BBF-03027 |
Verlamelin (74758-64-8) Inquiry |
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It is a depsipeptide antibiotic produced by the strain of Fungi MF 4683. It has anti-fungal activity against plant pathogens. |
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| BBF-03422 |
Trichodermin (4682-50-2) Inquiry |
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Trichodermin is a terpenoid antibiotic which has anti-fungal and protozoal effects. It is originally isolated from Trichoderma viride. |
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| BBF-05736 |
Polyoxorim (22976-86-9) Inquiry |
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Polyoxorim is a member of the class of polyoxins that is isolated from the soil organism Streptomyces cacaoi var. asoensis. Polyoxorim exhibits fungicidal properties and may be used on rice, industrial grounds, golf courses and parks. It has a role as an EC 2.4.1.16 (chitin synthase) inhibitor and an antifungal agrochemical. It is a polyoxin and an antibiotic fungicide. |
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| BBF-05831 |
Nikkomycin Z from Streptomyces tendae (59456-70-1) Inquiry |
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Nikkomycin Z is a nucleotide peptide from Streptomyces tendae with antifungal effects. Nikkomycin Z is a selective and competitive inhibitor of chitin synthesis and acts as a competitive analog of the chitin synthetase substrate UDP-N-acetylglucosamine. |
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| BBF-05832 |
O-Desulfo Micafungin (539823-80-8) Inquiry |
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O-Desulfo Micafungin is an impurity of caspofungin or micafungin. Micafungin is a polyene antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. |
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| BBF-05833 |
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FR 901379 is an impurity of Micafungin, a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species. FR901379 is an echinocandin-like antifungal lipopeptide with inhibitory activity against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR 901379 has a protective effect against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of lung cysts and trophozoites in a mouse model of Plasmodium carinii infection. |
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| BBF-05835 |
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1-[(4R,5R)-4,5-dihydroxy-L-ornithine]-Echinocandin B is an intermediate of Anidulafungin, an echinocandin antifungal drug. |
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| BBF-05840 |
Diniconazole (83657-24-3) Inquiry |
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Diniconazol is a chemical compound belonging to chlorine group of conazole. It is used as a fungicide. It inhibited lanosterol 14 alpha-demethylation catalyzed by a yeast cytochrome P-450 strongly. |
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| BBF-05890 |
Aminocandin (227472-48-2) Inquiry |
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Aminocandin, a new representative of the echinocandins, has broad-spectrum in vitro activity against Aspergillus and Candida spp. It is used as an anti-infective agent and antifungal drug. It acts by targeting glucans in the fungal cell walls. |
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| BBF-05891 |
Tetrahydroechinocandin B (54651-06-8) Inquiry |
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Tetrahydroechinocandin B, a cyclic hexapeptide containing a fatty acyl side chain, inhibits 1,3-beta-D-glucan synthesis. It is an intermediate of anidulafungin. |
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| BBF-05906 |
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Triclosan is a broad-spectrum antibacterial and antifungal agent added in consumer products such as toothpaste, soaps, detergents, etc. |
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| BBF-05908 |
Dichlorophen (97-23-4) Inquiry |
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Dichlorophen is an antimicrobial agent with activity against cestodes, protozoa, fungi, and bacteria. |
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| BBF-04146 |
Aureobasidin A (127785-64-2) Inquiry |
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Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase. |
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| BBF-01827 |
Deoxymulundocandin (138626-63-8) Inquiry |
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Deoxymulundocandin is an echinocandin antifungal agent isolated from Aspergillus sydowii. |
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| BBF-02614 |
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Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis. |
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| BBF-05834 |
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FR 179642 is an impurity of Micafungin, which is an antifungal agent. |
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| BBF-04053 |
Micafungin sodium (208538-73-2) Inquiry |
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Micafungin Sodium is an inhibitor of 1,3-beta-D-glucan synthesis, used as an antifungal drug. |
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| BBF-02576 |
Pneumocandin B0 (135575-42-7) Inquiry |
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Pneumocandin B0 is a lipopeptide antibiotic produced by Zalerion arboricola. It has a strong anti-Candida effect. It has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC50 of 0.07-0.5 μg/mL. |
As a leading fermentation CDMO, BOC Sciences has the capability and experience to provide top-quality and high-purity antifungal products for pharmaceutical, biotechnology and agriculture.
Fermented Products as Antifungal Agents
Fungal infections can range from superficial skin conditions to life-threatening systemic diseases. Traditional antifungal treatments have been effective, but concerns about drug resistance and side effects have sparked interest in alternative approaches. In recent years, fermented bioactive metabolites have emerged as a promising avenue in the quest for effective antifungal agents. The fermentation process itself offers numerous advantages, including sustainability, high purity, diverse sourcing, cost-effectiveness, and the potential for innovation in antifungal drug development. Fermentation can yield various secondary metabolites with antifungal properties, including phenolic compounds, flavonoids, and other bioactive molecules.
Antifungal Compounds Production by Fermentation
Fermentation is a versatile and sustainable method for producing antifungal compounds. Microorganisms like bacteria, yeast, and fungi can be manipulated to generate these compounds in large quantities. The process typically involves the following steps:
- Isolation of Microorganisms: The isolation of specific microorganisms known to produce antifungal compounds or engineering of them to enhance their antifungal properties.
- Fermentation: The isolated microorganisms are cultured in bioreactors under controlled conditions. During fermentation, they produce the desired antifungal metabolites.
- Extraction and Purification: Once fermentation is complete, the antifungal compounds are extracted from the culture broth and purified to remove impurities.
- Formulation: The purified compounds can be formulated into various pharmaceutical or agricultural products depending on their intended use.
Classification of Fermented Antifungal Agents
Fermented antifungal agents can be classified into several chemical categories based on their chemical structure and mode of antifungal activity. Here are some common chemical classifications:
- Polyenes: Polyene antifungal agents are characterized by their polyene macrolide structure. They include compounds like amphotericin B and nystatin. These agents disrupt fungal cell membranes by binding to ergosterol, a key component of fungal cell membranes, leading to membrane permeability and cell death.
- Azoles: Azole antifungal agents are synthetic compounds that inhibit fungal growth by interfering with ergosterol synthesis, a critical component of fungal cell membranes. Common azoles include fluconazole, itraconazole, and ketoconazole. While these are typically synthetic, some may have analogs produced through fermentation.
- Echinocandins: Echinocandins are a class of antifungal agents that target the fungal cell wall by inhibiting the synthesis of beta-glucan, a key structural component. Caspofungin, micafungin, and anidulafungin are examples of echinocandin antifungals.
- Alkaloids: Some antifungal agents are alkaloids produced by certain fungi. For example, griseofulvin is an antifungal alkaloid produced by Penicillium griseofulvum. It disrupts fungal cell division by binding to microtubules.
- Terpenoids: Terpenoid antifungal agents are derived from natural sources and include compounds like miconazole and terbinafine. They inhibit fungal cell membrane synthesis by targeting enzymes involved in sterol biosynthesis.
- Peptides: Peptide antifungal agents are often produced by fermentation. They can have diverse structures and mechanisms of action. Examples include ciclopirox and echinocandins.
- Bacteriocins: Bacteriocins are antimicrobial peptides produced by bacteria, some of which can exhibit antifungal properties. Nisin, produced by Lactococcus lactis, is an example of a bacteriocin with antifungal activity.
- Enzymes: Certain enzymes produced through fermentation can have antifungal properties. For example, chitosanase enzymes can degrade chitin, a major component of fungal cell walls, leading to fungal cell lysis.
- Natural Products: Fermentation can also be used to produce and modify natural products with antifungal activity. Examples include various polyketides, terpenes, and alkaloids.
Applications of Fermented Bioactive Metabolites with Antifungal Effects
- Infection Treatments: Fermented bioactive metabolites are commonly used in topical antifungal treatments. Creams, powders, or oral or intravenous drugs containing these compounds can be applied for fungal infections.
- Agriculture and Horticulture: Fermented bioactive metabolites are also used in agriculture and horticulture to protect crops and plants from fungal diseases. These compounds can be applied as natural fungicides.
- Animal Health: Fungal infections can also affect animals, including livestock and pets. Fermented bioactive metabolites are employed in veterinary medicine to treat fungal infections in animals.
