Antineoplastic

Catalog	Product Name / CAS / Description	Structure
BBF-05719	Siomycin (11017-43-9) Inquiry
	Siomycin is a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G and aminoacyl-tRNA. It exhibits antitumor activity against certain cancer cell lines.
BBF-05720	Stambomycin A (1263082-06-9) Inquiry
	Stambomycin A is a macrolide antibiotic with promising antitumor activity.
BBF-05721	Tallysomycin (67995-68-0) Inquiry
	Tallysomycin is an antitumor antibiotic complex produced by actinomycetes strain No. E465-94 with antibacterial and antifungal activity. It consists of two major components, A and B.
BBF-05722	Jadomycin B (149633-99-8) Inquiry
	Jadomycin B is an angucyclic natural product produced by Streptomyces venezuelae ISP5230. It exhibits antimicrobial, antitumor activity and inhibits aurora-B kinase and DNA cleaving. It was also shown to be effective against a variety of staphylococci.
BBF-05851	3-(Methylseleno)-L-alanine (26046-90-2) Inquiry
	3-(Methylseleno)-L-alanine, a metabolite found in Escherichia coli (strain K12, MG1655), is an inhibitor of DMBA-induced mammary tumors. It has oral bioavailability and can induce cell apoptosis.
BBF-05858	4'-epi-Daunorubicin Hydrochloride (56390-08-0) Inquiry
	4'-epi-Daunorubicin Hydrochloride is an impurity of Daunorubicin, which is an anthracycline antibiotic used in the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression.
BBF-05861	Irinotecan (97682-44-5) Inquiry
	Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death.
BBF-05862	Epirubicin (56420-45-2) Inquiry
	Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. It is clinically active against a broad range of tumor types, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostatic carcinoma, transitional bladder carcinoma and so on.
BBF-05863	Bleomycin (11056-06-7) Inquiry
	Bleomycin is complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. It is a medication used to treat cancer, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. It was initially developed by Bristol-Myers Squibb and has been listed.
BBF-05864	Berubicin Hydrochloride (293736-67-1) Inquiry
	Berubicin hydrochloride is the hydrochloride of berubicin, which is an anthracycline derivative used as a topoisomerase II inhibitor with activity in ependymoma. Berubicin hydrochloride has potential antineoplastic activity.
BBF-05865	Distamycin (39389-47-4) Inquiry
	Distamycin is an anticancer antibiotic with antiviral and antiprotozoal activity.
BBF-05870	Neocarzinostatin (9014-02-2) Inquiry
	Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic produced by Str. carzinostatiuns var. neocarzinostaticus F41. It can resist gram-positive bacteria and is clinically used in acute myelogenous leukemia, acute lymphocytic leukemia, pancreatic cancer, etc.
BBF-05883	Vinblastine (865-21-4) Inquiry
	Vinblastine, an inhibitor of nAChR, is a natural alkaloid isolated from the plant Vinca rosea Linn. It binds to tubulin and inhibits microtubule formation, leading to disruption of mitotic spindle assembly and arrest of tumor cells in the M-phase of the cell cycle. It may also interfere with the metabolism of amino acids, cyclic AMP, and glutathione. It is used to treat malignant lymphoma.
BBF-05892	Cryptophycin 1 (124689-65-2) Inquiry
	Cryptophycin 1, produced by Nostoc sp. GSV 224, is a potent cytotoxic anti-microtubule agent. Cryptophycin 1 can induce cell apoptosis, and has anti-tumor activity and excellent anti-proliferation ability.
BBF-05893	Telomestatin (265114-54-3) Inquiry
	Telomostatin, originally isolated from the bacteria Streptomyces anulatus, is a potent and specific telomerase inhibitor that acts only on human telomere sequences and does not affect DNA polymerases or reverse transcriptases. Telomostatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.
BBF-05894	Ibrutinib (936563-96-1) Inquiry
	Ibrutinib is a potent and selective BTK inhibitor (IC50=0.5 nM).
BBF-05895	O-Acetylbenzeneamidinocarboxylic acid (82744-16-9) Inquiry
	O-Acetylbenzeneamidinocarboxylic acid is isolated from Gibberella saubinetii with antitumor activity. It has weak inhibitory effect on tumor cells.
BBF-05896	Aclacinomycin (66676-88-8) Inquiry
	Aclacinomycin is an anthracycline drug that is used in the treatment of cancer.
BBF-05900	Actidione (66-81-9) Inquiry
	Actidione, an inhibitor of eukaryotic protein synthesis, is an antibiotic isolated from the beers of Streptomycin-producing strains of Streptomyces griseus. Actidione is used as a fungicide and anticancer drug.
BBF-05912	Pladienolide D (445487-91-2) Inquiry
	Pladienolide D is an antitumor macrolide produced by Streptomyces platensis.

BOC Sciences is a leading CDMO, providing a variety of biologically derived antineoplastic compounds. For decades, we have been focusing on fermentation projects, including strain development, fermentation process optimization, and downstream processing. We offer industrial fermentation services to customize the production of antineoplastic reagents for you.

Fermented Bioactive Metabolites as Antineoplastics

The production of antineoplastic compounds through fermentation offers numerous advantages, including sustainability, high purity, diverse sourcing, cost-effectiveness, reduced drug resistance, and the potential for innovation. As research and development in this field continue to expand, fermented bioactive metabolites may play an increasingly significant role in the fight against cancer.

Fermented bioactive metabolites with antineoplastic properties are a diverse group of compounds that can be classified into several categories based on their chemical structure, source, and mechanisms of action.

• Polyketides: Polyketides are a class of compounds produced by various microorganisms during fermentation. Examples of polyketides with antineoplastic effects include doxorubicin and epothilones. Doxorubicin, produced by Streptomyces peucetius, is widely used in cancer chemotherapy due to its ability to inhibit DNA synthesis in cancer cells. Epothilones, produced by Sorangium cellulosum, disrupt microtubule dynamics, hindering cell division in cancer.
• Peptides: Certain peptides produced through fermentation exhibit antineoplastic properties. For instance, l-asparaginase, derived from Escherichia coli or Erwinia chrysanthemi, is used in leukemia treatment by depleting asparagine, a vital nutrient for cancer cells.
• Alkaloids: Alkaloid antineoplastic agents are often isolated from fermented plant sources. Vincristine and vinblastine, produced by Catharanthus roseus, are examples. These alkaloids disrupt microtubule formation, arresting cell division in cancer cells.
• Small Molecules: Some fermented bioactive metabolites with antineoplastic effects are small molecules with diverse structures. For instance, curcumin, a polyphenolic compound produced during fermentation, exhibits anti-inflammatory and anticancer properties by modulating various molecular pathways.
• Fungal Metabolites: Certain fungal metabolites produced through fermentation have shown potent antineoplastic activity. Examples include taxanes like paclitaxel, derived from the bark of Taxus brevifolia, and camptothecins like irinotecan and topotecan, derived from Camptotheca acuminata.

Applications of Fermented Antineoplastic Agents

Antineoplastic agents, derived from the fermentation process involving microorganisms, have found various applications in the field of oncology.

• Chemotherapy: Fermented antineoplastic agents are integral components of chemotherapy regimens. They inhibit the growth of malignant cells, induce apoptosis (cell death), and slow down tumor progression. Examples include doxorubicin, paclitaxel, and vinblastine.
• Targeted Therapies: Some fermented bioactive metabolites are used in targeted cancer therapies. Small molecules derived from fermentation can selectively target specific cancer cell markers or signaling pathways, reducing harm to healthy cells. In addition, fermented bioactive metabolites have emerged as promising candidates for use as antibody-drug conjugate (ADC) payloads in the field of targeted cancer therapy.
• Combination Therapies: Combining fermented antineoplastic agents with other treatment modalities, such as radiation therapy or immunotherapy, can enhance treatment outcomes. These combinations can improve the overall effectiveness of cancer treatment.
• Prevention and Chemoprevention: Certain fermented bioactive metabolites have demonstrated chemopreventive properties. They can help prevent the initiation, promotion, or progression of cancer. For example, curcumin, a polyphenolic compound produced during fermentation, has anti-inflammatory and anticancer properties and is investigated for its preventive potential.

Examples of Fermented Bioactive Metabolites as ADC Payloads

• Maytansinoids: Maytansinoids are naturally occurring metabolites produced by certain plant species, but they can also be obtained through fermentation. Maytansinoid-based ADCs, such as ado-trastuzumab emtansine, have shown efficacy in breast cancer treatment. They disrupt microtubules, leading to cancer cell death.
• Auristatins: Auristatins are synthetic derivatives of naturally occurring metabolites from marine sponges. They can be produced through fermentation and are used in ADCs like brentuximab vedotin. Auristatins inhibit tubulin polymerization, disrupting cancer cell division.
• Duocarmycins: Duocarmycins are a class of potent DNA-alkylating agents produced by Streptomyces bacteria. These metabolites can be used as ADC payloads to target and destroy cancer cells by causing DNA damage.