Antineoplastic

14-O-Acetylindolactam V is an antibiotic isolated from the Actinomyces NA34-17. 14-O-Acetylindolactam V has the effect of inducing early Epstein-Barr virus antigen.

Acetomycin is an anti-human tuberculosis and amoeba antibiotic isolated from the Streptomyces ramnlosus. Acetomycin is an anti-biotic, anti-fungal, anti-protozoal, and anti-bacterial agent

Chromomycin A3 is produced by the strain of Streptomyces olivochromogenes 69895. The major component of the chromomycin complex of the aureolic acid class; isolated from several streptomyces species; exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent; binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity.

It is produced by the strain of Streptomyces griseolus. It inhibits protein synthesis. it has anti-fungal, anti-fine bacteria, anti-tumor and antigenic insect action.

It is produced by the strain of Streptomyces refuineus var. thermotolerans. It has a weak activity against gram-negative bacteria, and has the effect of inhibiting metamorphoses, vaginal trichomonas and rat tube nematode. It has inhibitory effect on sarcoma 180, L-1210, CA-755, Ascitic ascites type and solid type cancer.

It is produced by the strain of Actinomadura carminata. Intravenous injection of 2 to 4 times of yangerythromycin (1.3-2.25mg) in mice could inhibit the growth of bronchial carcinoma, transplanted gastric cancer, lymphoid leukemia L-1210 and lymphosarcoma, but had poor effect on sarcoma-180 and lymphangiopathy, and had no effect on Eilinite ascites carcinoma.

Epothilons B is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum. It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi.

Epothilons A is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum. It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi.

It is produced by the strain of Streptomyces distallicus NCIB 8936. It has the activity against gram-positive bacterium, mycobacterium, dermatophyte and Trichophyte. It has inhibitory effects on solid tumors such as Epstein-Barr ascites carcinoma, sarcoma 180, Walker 258, oberling-Guerin osteoma, and also inhibits vaccinosis virus, herpes simplex virus, adenovirus, and mouse hepatitis virus in cell culture.

It is produced by the strain of Streptomyces echinatus. It has the activity of anti-gram-positive bacteria and vaginal trichomonas, and also has the effect on influenza virus and sarcoma 180 cells in vitro.

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein is developed to be an antitumor agent. Genistein has antioxidant effect, it can be used in cosmetics material.

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an anti-infective and antiangiogenic agent.

Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits heat shock protein 90 (HSP90). Geldanamycin has been shown to promote survival of neural stem cells from oxidative stress via inhibition of HSP90. It displays potent antineoplastic properties and inhibits myeloma cell growth.

Illudin M is a natural sesquiterpene agent with strong anti-tumour activity.

Illudin S is a natural sesquiterpene agent with strong anti-tumour activity. Illudin S inhibits DNA synthesis via an unknown mechanism.

KRX-0601, also known as UCN-01, is a synthetic derivative of staurosporine with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting apoptosis.

Rhodomycin A is originally isolated from Str. purpurascens 340. It has the activity of anti-gram-positive bacteria and weak effect on anti-gram-negative bacteria and fungi.