Bioactive by-products
| Catalog | Product Name / CAS / Description | Structure |
|---|---|---|
| BBF-04634 |
1-Hydroxypyridine-2-thione zinc salt (13463-41-7) Inquiry |
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Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. |
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| BBF-04640 |
Cetylpyridinium Chloride Monohydrate (6004-24-6) Inquiry |
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It has a broad-spectrum antimicrobial activity, a rapid bactericidal effect on Gram-positive pathogens and a fungicide effect on yeast, and is used as an oropharyngeal preservative. |
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| BBF-04645 |
Bactenecin (116229-36-8) Inquiry |
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A cyclic, 12 amino acid antimicrobial peptide (AMP) with antibacterial activity against gram-negative and some gram-positive bacteria. |
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| BBF-05257 |
Sclerotigenin (65641-84-1) Inquiry |
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Sclerotigenin is a natural benzodiazepine originally isolated from Penicillium sclerotigenum that acts as an insect growth regulator and has an anti-insectan activity against the caterpillar, Helicoverpa zea. |
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| BBF-05259 |
Tuliposide A (19870-30-5) Inquiry |
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Tuliposide A is a sugar ester derived from the common tulip, consisting of D-GLC and 4-hydroxy-2-methylenebutanoyl. Tuliposide A has antibacterial activity. |
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| BBF-05357 |
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| BBF-05408 |
Protocetraric acid (489-51-0) Inquiry |
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Protocetraric acid has strong antioxidant, antibacterial and anticancer effects. |
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| BBF-05412 |
Divaricatic acid (491-62-3) Inquiry |
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Divaricatic acid, a secondary metabolite produced by lichens of the genus Ramalina, has molluscicidal and antiparasitic activities. |
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| BBF-05488 |
Heliantriol B2 (61229-18-3) Inquiry |
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Heliantriol B2 is a natural compound which can be isolated from Chuquiraga erinacea and Monteverdia apurimacensis, etc. |
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| BBF-05614 |
Prasinic acid (90332-21-1) Inquiry |
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Prasinic acid shows moderate antitumor activity in different lines of cancer cells. |
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| BBF-05710 |
Ansamitocin PDM-3 (77353-69-6) Inquiry |
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Ansamitocin PDM-3 is an ansamycin antibiotic isolated from Actinosynnema pretiosum, and exhibits antitumor activity. |
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| BBF-05724 |
Enfumafungin (260979-95-1) Inquiry |
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Enfumafungin is a triterpene glycoside and hemiacetal isolated from a fermentation of Hormonema sp. Enfumafungin is an antifungal agent that acts on fungal cell walls as an inhibitor of (1,3)-beta-D-glucan synthase. It is specific for yeast and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis. |
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| BBF-05919 |
Milbemycin B2 (51596-12-4) Inquiry |
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Milbemycin B2 is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05920 |
20-oxomilbemycin A4 (86691-97-6) Inquiry |
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20-oxomilbemycin A4 is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05921 |
20-oxomilbemycin A3 (86691-98-7) Inquiry |
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20-oxomilbemycin A3 is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05922 |
Milbemycin D oxime (93074-02-3) Inquiry |
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Milbemycin D oxime is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05923 |
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8-desmethylmilbemycin A4 oxime is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05924 |
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20a-hydroxy-20-oxomilbemycin A4 is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05925 |
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(20'R)-Hydroxymilbemycin A4 keto form is a derivative of Milbemycin, a group of macrolides originaly isolated from Streptomyces hygroscopicus. Milbemycins are used in veterinary field for antiparasitic activity. |
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| BBF-05925 |
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BOC Sciences is a leading CDMO company, and we have been focusing on fermentation projects, including strain development, fermentation process optimization, and downstream processing. We have been committed to providing customers with diverse, high-quality Bioactive by-products derived from fermentation and isolation of plants, microorganisms, fungi, and other organisms at the best prices.
What are Bioactive by-products?
Bioactive by-products are diverse, high-quality by-products derived from plants, microorganisms, fungi, and other organisms through fermentation and separation techniques. These active by-products have attracted great attention from researchers and industry in recent years due to their excellent biological activity and wide application prospects.
Sources of Bioactive by-products
The main sources of bioactive by-products include organisms such as plants, microorganisms, fungi, etc. Through fermentation technology, these organisms can produce a variety of specific products with biological activity and by-products under specific conditions. Among them, microbial metabolites are an important part of it, which has attracted extensive attention because of its excellent effect and increasing variety and yield. For example, antibiotics, antineoplastic drugs, immunosuppressants, and antifungal drugs can all be produced by microbial fermentation.
Production process of Bioactive by-products
The production of microbial metabolites involves complex fermentation processes and extraction methods. Different metabolites require specific fermentation conditions and media to ensure their yield and quality. For example, the production of penicillin requires the penicillium to ferment in a specific medium, while the production of streptomycin relies on the specific fermentation process of the streptomyces. The waste liquid produced during the fermentation process often contains a large number of metabolic by-products, which can be reused after proper treatment, so as to achieve efficient use of resources and environmental protection.
In addition, modern extraction and separation technologies play a crucial role in the reuse of bioactive by-products. With advanced separation technology, valuable metabolites can be efficiently extracted from the fermentation broth. For example, technologies such as centrifugation, ultrafiltration, reversed-phase high-performance liquid chromatography (RP-HPLC), and supercritical fluid extraction (SFE) have been widely used in the extraction and separation of bioactive by-products. These technologies not only improve the extraction efficiency, but also maintain the biological activity and purity of the product.
Application of Bioactive by-products
Bioactive by-products have a wide range of applications in medicine, agriculture, food, environmental protection and other fields.
Pharmaceutical field: Many bioactive by-products have a variety of biological activities such as antibacterial, antitumor, antiviral, antifungal, etc. For example, drugs such as penicillin, streptomycin, doxorubicin, and cyclosporine are obtained through microbial fermentation. These drugs play an important role in the treatment of various diseases and have greatly contributed to the development of modern medicine.
Agriculture: Some microbial metabolites can be used as agricultural biological agents to improve the growth and disease resistance of crops. For example, residual metabolites or derivatives in the waste of chlortetracycline production have a strong growth-promoting effect. In addition, the residue after diurnal Streptomyces fermentation can be used as protein in feed, providing animal nutrition and is non-toxic.
Food: Bioactive by-products are also widely used in the food industry. For example, some microbial metabolites can act as natural preservatives and extend the shelf life of foods. Some metabolites can be used as functional food ingredients to enhance the nutritional value and health function of food.
Environmental protection: Bioactive by-products play an important role in environmental protection. For example, biosurfactants can be used for environmental remediation and oil degradation; Some microbial metabolites can be used to treat industrial wastewater and soil contamination.
Application examples of Bioactive by-products
Metabolic by-products
Metabolic by-products are substances produced by organisms during metabolic processes, some of which have important biological activity and commercial value. For example, Divaricatic acid is a secondary metabolite produced by lichens of the genus Ramalina with significant molluscidal and antiparasitic activity. This substance can be used in agriculture and medicine to provide a natural means of pest control. Phanerosporic acid, on the other hand, is a secondary metabolite isolated from the fungus Phanerochaete chrysosporium and exhibits strong antimicrobial and antifungal activity. These metabolites have potential applications in antibiotic research and development to help fight bacterial and fungal infections. Another example is byproducts of alcoholic fermentation, Saccharomyces cerevisiae produces metabolites such as higher alcohols, esters, aldehydes, phenols, acids, and diketones in addition to ethanol, the main metabolite, these yeast fermentation byproducts can be used in food and industry.
Fermentation residue and broth
In industrial production, the fermentation process not only produces the target product, but also generates a large amount of fermentation residue and waste liquid. For example, the residual metabolites or derivatives in the waste liquid during the production of chlortetracycline have a strong growth-promoting effect on crops. These by-products can be used as organic fertilizers or plant growth regulators to promote agricultural production and increase crop yields. Similarly, the residues from the fermentation of Streptomyces can be used as a source of protein in feed, providing animal nutrition and is non-toxic. This non-toxic protein additive helps reduce feed costs, improve livestock production efficiency, and promote environmental protection and resource recycling.
Fermentation of by-products
Many agricultural by-products or by-products of the food industry can be used as raw materials to produce bioactive substances through fermentation and realize the use of waste. For example, agricultural by-products such as fruit and vegetable residues can be converted into bioactive substances with high added value, such as enzymes, antibiotics, vitamins, etc., after microbial fermentation. This kind of waste resource utilization not only reduces the environmental pressure of waste treatment, but also improves the efficiency of resource utilization, reflecting the concept of green production.
Advantages of Bioactive by-products
The production process of Bioactive by-products can be optimized by modern fermentation technology, improving the utilization of resources and energy, reducing the use of toxic substances and the generation of waste, and reducing environmental pollution. For example, the use of agricultural by-products or by-products of the food industry as raw materials for fermentation can be used to reuse waste and reduce the pressure on the environment. At the same time, by improving the fermentation process and extraction technology, the yield and quality of Bioactive by-products can be improved, and its market competitiveness can be enhanced.
References
- Oh, Jong Min, et al., Antimicrobial activity of divaricatic acid isolated from the lichen Evernia mesomorpha against methicillin-resistant Staphylococcus aureus. Molecules 23.12 (2018): 3068.
- Arnone, Alberto, et al., Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytochemistry 28.10 (1989): 2803-2806.
