Bioactive by-products

Mycoplanecin C is a cyclic peptide compound produced by Actinoplanes aivajinensis subsp. mycoplanecinus.

Mycoplanecin D is a cyclic peptide compound produced by Actinoplanes aivajinensis subsp. mycoplanecinus.

Mycotrienol I is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.

Mycotrienol II is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.

Nocathiacin I is produced by the strain of Nocardia sp. WW-12651. It is highly resistant to gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF).

Oganomycin A is produced by the strain of Str. oganonensis Y-G 19Z. It is more stable than cephalosporin and resistant to gram-positive and negative bacteria. And it is more effective against gram-negative bacteria than gram-positive bacteria.

Oganomycin B is produced by the strain of Str. oganonensis Y-G 19Z. It is more stable than cephalosporin and resistant to gram-positive and negative bacteria. And it is more effective against gram-negative bacteria than gram-positive bacteria.

Quinocitrinine B is produced by the strain of Penicillum citrinum Thom 1910. It has moderate anti-gram positive and negative bacterial and fungal activity. And it also shows moderate antiproliferative activity to L-929, K-562 and HeLa cells.

Quinolactactin A is a quinolone fungal metabolite that inhibits TNF production induced by LPS in murine peritoneal macrophages.

Rasfonin is a fungal metabolite that has been found in Talaromyces sp. 3656-A1. It is a Ras-dependent apoptosis inducer that induces apoptosis in Ras-dependent cells such as Ba/F3-V12 cells.

Rhodopeptin C1 is a cyclic tetrapeptide originally isolated from Rhodococcus sp. Mer-N1033. It has anti-candida and cryptococcus neoformant activities, and the MIC (μg/mL) was 1.25~2.5 and 0.63~1.25, respectively.

Rhodopeptin C2 is a cyclic tetrapeptide originally isolated from Rhodococcus sp. Mer-N1033. It has anti-candida and cryptococcus neoformant activities, and the MIC (μg/mL) was 1.25~2.5 and 0.63~1.25, respectively.

Rhodopeptin C3 is a cyclic tetrapeptide originally isolated from Rhodococcus sp. Mer-N1033. It has anti-candida and cryptococcus neoformant activities, and the MIC (μg/mL) was 1.25~2.5 and 0.63~1.25, respectively.

Ripromycin is produced by the strain of Streptomyces sp Tu 6239. It has moderate anti-gram-positive bacterial activity, but not anti-gram-negative bacteria or fungi. It inhibited the proliferation of HM02 and MCF cells with IC50 of 1.6 and 2.0 μg/mL, respectively.

Roridin C is a fungal sesquiterpene derived from Myrothecium roridum S-1135 (NRRL 3005).

Roridin D is originally isolated from Myrothecium roridum S-1135 (NRRL 3005).

Roridin E is originally isolated from Myrothecium roridum S-1135 (NRRL 3005).

Roridin J is originally isolated from Myrothecium roridum S-1135 (NRRL 3005) and it has anti-leukemia effect in mice.

Roridin L2 is originally isolated from M. roridum var. and it has antibacterial and antitumor effects.

It is produced by the strain of Str. coeruleorubidus AB 1183F-64. It has inhibitory effect on Pseudomonas aeruginosa. It also has effect on a few strains of bacteria such as suppurative staphylococcus and Escherichia coli. Serum can reduce its antibacterial activity, pH also affects its antibacterial activity. pH 6.5, The antibacterial activity of Pacidamycin 1 can be enhanced twice. In vivo test of mice infected with pseudomonas aeruginosa (100 mg/kg·d) showed no protective effect.