Bioactive by-products

Anhydroepiophiobolin A is an ophiobolin with a broad biological profile. It has antibacterial, antifungal, antitumour, herbicidal and nematocidal activities. It is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many bipolaris species.

It is a neutral linear peptaibol complex with potent antimicrobial activity, containing 20 amino acids with an acetyl and phenylalaninol termini, produced by trichoderma sp. It is an ionopohore, transporting ions through membranes and artificial lipid membrane. It forms voltage-dependent ion channels in lipid bilayer membranes.

It is a base-catalysed intermediate in the decomposition of avermectin B1a. It has only very weak activity as a nematocide showing 100-fold less of biological activity compared with the parent avermectin. It is an environmental degradation product.

It is a minor co-metabolite of enterocin produced by several species of streptomyces. It exhibits activity against both gram-positive and gram-negative bacteria.

It is a simple aromatic siderophore produced by several species of pseudomonas. It exhibits antibacterial, antifungal and antitumor activity.

It is a simple phenazine produced by several species of streptomyces. It is a weakly active antibacterial metabolite with activity against Sarcina lutea and mycobacteria. Dimethoxyphenazine and related phenazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.

It is a minor hydrophobic analogue of cercosporin produced by several species of the fungal genera, cercospora and septoria. It has moderate in vitro activity against leishmania and chloroquine-sensitive strains of plasmodium falciparum. It exhibits antitumor activity.

It is a potent antitumour metabolite isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. It's cytotoxic.

It is a minor analogue of a potent antitumour complex isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin.

It is the major analogue of a potent antitumour complex isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin.

It is produced by the strain of Streptomyces. It is a potent nematocide and insecticide belonging to the bafilomycin class. It also has anti-fungal properties.

It is a chromone isolated from the filamentous fungus, lachnum sp. It possesses weak activity against bacteria but has not been extensively investigated.

It is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. It shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Mutilin, is used to perform biological studies with focus on antimicrobial activity. It is a minor metabolite of the pleuromutilin family isolated from pleurotus mutilus.

It is the dehydrated analogue of ophiobolin A and a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus bipolaris. It possesses a broad biological profile with antibacterial, antifungal, antitumour, herbicidal and nematocidal activities.

It is the major component of a family of cyclic lipopeptides produced by pseudomonas fluorescens pf-5. It is a moderate antifungal agent. It has a profound effect on the swarming motility of bacteria on agar surfaces.

It is a minor metabolite from the oligomycin complex produced by several species of streptomyces. It exhibits weak antibacterial activity and is considerably weaker as an antifungal agent.

It is an unusual sesquiterpene metabolite isolated from aspergillus terreus. It exhibits antitumor activity.

It is a broad spectrum antifungal metabolite isolated from several species of fusarium. It exhibits low animal-toxicity as evidenced by a lack of toxicity against artemia salina. It is a useful candidate for control of postharvest crop diseases.

A novel antibacterial analogue of the sulfonamide antibiotic, Sulfamethoxazole.