Bioactive by-products

RP-1551-4 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1551-5 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1551-6 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1551-7 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1551-8 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1551-9 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor.

RP-1776 is a cyclic peptide isolated from the culture broth of Streptomyces sp. KY11784. It selectively inhibits the binding of PDGF BB to the extracellular domain of the PDGF beta-receptor with an IC50 value of 11 ± 6 µmol/L.

RP-66453 is a secondary peptide metabolite produced by Streptomyces sp. A 9738. It can selectively bind to neurotensin receptor.

S14-95 is an inhibitor of the JAK/STAT pathway isolated from Penicillium sp. 14-95. It inhibits the IFN-gamma mediated expression of the reporter gene with IC50 values of 2.5 to approximately 5 mg/ml. It inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 5 microg/ml (10.8 mM) in LPS/IFN-gamma stimulated J774 mouse macrophages.

S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans.

FA 5859 is an amino acid compound produced by the strain of Emericella quidrilineata (IFO 5859), Aspergillus sp. 3704. It has the activity of inhibiting fatty acid degradation.

Pironetin is a plant growth regulator produced by Streptomyces sp. NK10958.

RES-701-1 is an endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. It selectively inhibits the ET-1 binding to endothelin type B receptor.

FR225659 is originally isolated from Helicomyces sp. No. 19353. It can suppress the gluconeogenesis induced by Glucagon in Primary hepatocytes of rats.

FR 900525 is a metabolite produced by the strain of Streptomyces tsukubaensis No. 9993. It has antifungal activity.

It is produced by the strain of Streptomyces sp. OM-5689. It has anti-Hela S3 activity (MIC is 0.39 μg/mL), similar to Glucopiericidin (MIC is 0.25 μg/mL).

It is produced by the strain of Streptomyces sp. OM-5689. It has anti-Hela S3 activity (MIC is 0.10 μg/mL), similar to Glucopiericidin (MIC is 0.25 μg/mL).

Small amphoteric polar metabolite produced by many streptomyces species; An important dereplication standard in discovery, displaying a distinctive UV spectrum and a broad range of biological activities, albeit weak; Demonstrated antiparasitic activity against trypanosomes by selective proline racemase inhibition and has potent antifungal activity against phytophthora.

Ivermectin B1b is a minor component of Ivermectin, a semi-synthetic derivative of Abamectin. Ivermectin is a medication that is effective against many types of parasites.

The less-active isomer of the DNA damanging, platinum antitumor drug cisplatin. Transplatin is used in the treatment of a variety of solid tumors. Transplatin's anti-tumor activity can be activated by light.