Bioactive by-products

SMTP-4 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin.

SMTP-5 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin.

SMTP-6 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin.

SW-163A is an immunosuppressant isolated from the culture broth of Streptomyces sp. SNA15896. It showed immunosuppressive and antimicrobial activities in vitro.

SW-163B is an immunosuppressant isolated from the culture broth of Streptomyces sp. SNA15896. It showed immunosuppressive and antimicrobial activities in vitro.

TAN-999 is an indolocarbazole derivative produced by Streptomyces sp. C-71799. It can activate macrophage in mice.

TAN-1030A is an indolocarbazole derivative produced by Streptomyces sp. C-71799. It can activate macrophage in mice.

TAN-1511A is a lipopeptide antibiotic isolated from the culture broth of Streptosporangium amethystogenes subsp. fukuiense AL-23456. It induced the secretion of both granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).

TAN-1511B is a lipopeptide antibiotic isolated from the culture broth of Streptosporangium amethystogenes subsp. fukuiense AL-23456. It induced the secretion of both granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).

TAN-1511C is a lipopeptide antibiotic isolated from the culture broth of Streptosporangium amethystogenes subsp. fukuiense AL-23456. It induced the secretion of both granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).

TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay.

TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM.

TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM.

TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM.

TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM.

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It exhibits anticancer activity against various cancer cell lines.

Trichostatin RK is a trigustatine derivative produced by the strain of Streptomyces sp. RK98-A74. It can induce luciferase, but its activity is lower than that of trigustatin.

Tryprostatin B is a natural compound isolated from Aspergillus fumigatus and arrests cell cycle progression at the G2/M phase.

Tuberin is produced by the strain of Str.amakusaensis 10-101 and it is resistant to mycobacteria.

Ustilipid A is originally isolated from Ustilago maydie DSM 11494. It has the activity of antagonizing dopamine D1 and D2 receptors with the IC50 (μg/mL) of 30 and 5, respectively.