Bioactive by-products

S14-95 is an inhibitor of the JAK/STAT pathway isolated from Penicillium sp. 14-95. It inhibits the IFN-gamma mediated expression of the reporter gene with IC50 values of 2.5 to approximately 5 mg/ml. It inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 5 microg/ml (10.8 mM) in LPS/IFN-gamma stimulated J774 mouse macrophages.

S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans.

FA 5859 is an amino acid compound produced by the strain of Emericella quidrilineata (IFO 5859), Aspergillus sp. 3704. It has the activity of inhibiting fatty acid degradation.

Pironetin is a plant growth regulator produced by Streptomyces sp. NK10958.

RES-701-1 is an endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. It selectively inhibits the ET-1 binding to endothelin type B receptor.

FR225659 is originally isolated from Helicomyces sp. No. 19353. It can suppress the gluconeogenesis induced by Glucagon in Primary hepatocytes of rats.

FR 900525 is a metabolite produced by the strain of Streptomyces tsukubaensis No. 9993. It has antifungal activity.

It is produced by the strain of Streptomyces sp. OM-5689. It has anti-Hela S3 activity (MIC is 0.39 μg/mL), similar to Glucopiericidin (MIC is 0.25 μg/mL).

It is produced by the strain of Streptomyces sp. OM-5689. It has anti-Hela S3 activity (MIC is 0.10 μg/mL), similar to Glucopiericidin (MIC is 0.25 μg/mL).

Small amphoteric polar metabolite produced by many streptomyces species; An important dereplication standard in discovery, displaying a distinctive UV spectrum and a broad range of biological activities, albeit weak; Demonstrated antiparasitic activity against trypanosomes by selective proline racemase inhibition and has potent antifungal activity against phytophthora.

Ivermectin B1b is a minor component of Ivermectin, a semi-synthetic derivative of Abamectin. Ivermectin is a medication that is effective against many types of parasites.

The less-active isomer of the DNA damanging, platinum antitumor drug cisplatin. Transplatin is used in the treatment of a variety of solid tumors. Transplatin's anti-tumor activity can be activated by light.

Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole. It is an antifungal medication commonly used in the treatment of fungal infections.

Sulfadoxine is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax. Sulfadoxine is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria. Due to high levels of resistance, its use is no longer recommended routinely.

Povidone-iodine can be used as a topical preservative. It has activity against Gram-positive and Gram-negative bacteria, fungi, parasites, viruses and yeast.

Fosfomycin calcium is the calcium salt form of Fosfomycin, produced by Streptomyces. Fosfomycin is an antibiotic that is primarily used to treat bladder infections. Fosfomycin inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA.

Flubendazole is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.

Nicarbazine is used as a preventive anticoccidial drug in chicken feed. It can reduce the egg hatching rate of urban bird pest species.

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.

Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.