Enzyme inhibitors

Thelephoric acid is a terphenylquinone pigment found in several fungi, such as Omphalotus subilludens and Polyozellus multiplex. It is derived from atromentin, and its precusor can be from cyclovariegatin. Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that plays a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease.

Polyporic acid is an intermediate in the biosynthesis of allantofuranone first isolated from a mycelial culture of the fungus species Hapalopilus nidulans. It inhibits the enzyme dihydroorotate dehydrogenase and has some antifungal and antibacterial activity.

Physciosporin (PHY) is an effective secondary metabolite found in lichens and isolated from Pseudocyphellaria coriacea. It inhibits the motility of lung cancer cells.

Mertensene, a halogenated monoterpene isolated from the red alga Pterocladiella capillacea (S.G. Gmelin) Santelices and Hommersand, induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling. It has antimicrobial and anti-algal properties, and it has insecticidal effect.

It is a lichen acid with enzyme inhibitory potential.

It has moderate inhibitory activity against the growth of Mycobacterium tuberculosis.

It is an inhibitor of Prostaglandin synthase with anti-oxidant activity and anti-radical power.

It is an inhibitor of Prostaglandin synthase.

It is an inhibitor of Prostaglandin synthase.

It is isolated from Streptomyces antibioticus. It shows DNA-binding properties and inhibits cholesterol biosynthesis.

It has inhibitory activity against S. pneumoniae, and this activity is stronger than Oleanolic acid.

It is extracted from the seeds of Magnolia fargesii CHENG (Magnoliaceae). It inhibits NF-κB and COX-2 and activates IκBα expression in CCl4-induced hepatic fibrosis. It has anti-inflammatory and anti-cancer activities against HepG2 cells as well as in BALB/C male mice.

In acidic condition, Anhydrofulvic acid inhibits mitochondrial respiration of Candida utilis using both succinate and cytochrome C as respiratory substrates, but not using NADH. Anhydrofulvic acid has antifungal activity.

Neoxaline is an alkaloid fungal metabolite originally isolated from Aspergillus japonicus. It inhibits the proliferation of Jurkat cells and induces cell cycle arrest at the G(2)/M phase.

Psoromic acid is a selective inhibitor of Rab geranylgeranyl transferase and P. falciparum fatty acid synthesis (FAS) II enzymes.

Polyoxorim is a member of the class of polyoxins that is isolated from the soil organism Streptomyces cacaoi var. asoensis. Polyoxorim exhibits fungicidal properties and may be used on rice, industrial grounds, golf courses and parks. It has a role as an EC 2.4.1.16 (chitin synthase) inhibitor and an antifungal agrochemical. It is a polyoxin and an antibiotic fungicide.

Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of the naturally occurring drug hirudin. It is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. It is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. It has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. It does not require a binding cofactor such as antithrombin and does not activate platelets.

Ibrexafungerp Citrate, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor.

Ibrexafungerp, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor.