Enzyme inhibitors

Pterulone is a Coenzyme I: Coenzyme Q oxidoreductase inhibitor produced by Pterula sp. 82168. It has anti-yeast and filamentous fungus effect.

Sch-38519 is an isochromanequinone structurally related to lactoquinomycin. It is isolated from Thermomonospora sp. SCC 1793. It inhibits thrombin-induced aggregation of human platelets and is active against gram-positive and gram-negative bacteria.

FR-235222 is an immunosuppressive substance that inhibits mammalian histone deacetylase (HDAC). It is produced by the strain of Acremonium sp. No. 27082.

It is a powerful β-lactam inhibitor originally isolated from Aspergollus candidus.

It is originally isolated from Flexibacter sp. No. 758. FR-901451 had inhibitory activity against HLE with ID50 of 2.3 X 10-7 mol/L. And it also has inhibitory effects on PPE, chymosin and proteinase.

FR901469 is an antifungal antibiotic produced by fungal sp. No. 11243. It inhibits the activity of 1, 3-β-glucan synthase, and has strong anti-Candida albicans and Aspergillus fumigatus activity in vitro and in vivo.

GE20372 A, a tetrapeptide, is produced by the strain of Streptomyces sp.. It is used as a human immunodeficiency virus (HIV-L) protease inhibitor.

GE20372 B is a tetrapeptide produced by the strain of Streptomyces sp.. It is used as a human immunodeficiency virus (HIV-L) protease inhibitor.

GERI-BP001 A is produced by the strain of Aspergillus fumigatus F37 with inhibitory activity against ACAT.

K-13 is a noncompetitive inhibitor of angiotensin I converting enzyme from Micromonospora halophytica subsp. exilisia K-13.

K-259-2, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was isolated from the cultured broth of Micromonospora olivasterospora K-259. IC50 values for the effect of K-259-2 against Ca2+ and calmodulin-stimulated activity of the enzyme preparations from bovine brain and heart were 6.6 and 2.9 microM, respectively.

It is produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115A inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide (IC50 = 100 microM), and the production of collagenase in IL-1 alpha-stimulated rat synovial cells (IC50 = 60 microM).

It is a co-produced compound of K-1115A produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115 B1 inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide, and the production of collagenase in IL-1 alpha-stimulated rat synovial cells.

It is a co-produced compound of K-1115A produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115 B2 inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide, and the production of collagenase in IL-1 alpha-stimulated rat synovial cells.

It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L.

It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L.

It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L.

It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L.

It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L.

It is produced by the strain of Streptomyces argenteolus A-2. Longestin inhibited Ca2+ and CAM-PDE in bovine brain with an IC50 of 0.065 μmol/L.