Enzyme inhibitors

It is a receptor antagonist produced by the strain of Stachybotrys sp. M6222. It inhibits the binding of I-ET-1 to rat ETA receptors with IC50 of 2.9 X 10-5 (mol/L). It also inhibits the binding of I-ET-1 to human ETA receptors and human ETB receptors with IC50 (mol/L) of 1.5 X 10-5 and 9.4 X 10-6, respectively.

It is a semaphorin inhibitor produced by the strain of Penicillinm sp. SPF-3059. It inhibits Semaphorin with IC50 of 0.1 μg/mL.

It is a semaphorin inhibitor produced by the strain of Penicillium sp. SPF-3059. It inhibits Semaphorin with IC50 of 0.09 μg/mL.

It is produced by the strain of Acremonium strcturn. It has the effect of inhibiting the binding of Flunitrazepam to γ-aminobutyric acid-benzodiazapine with IC50 of 40 nmol/L.

It is produced by the strain of Streptomyces diastatochromogenes B59. It can inhibit the signal transduction of thaliphin.

It is produced by the strain of Actinomadura sp. 937ZB-1. It has an inhibitory effect on the Angiotensin I converting enzyme.

It is produced by the strain of Actinomadura sp. 937ZB-1. It has an inhibitory effect on the Angiotensin I converting enzyme.

It is a 3-α-hydroxysteroid dehydrogenase inhibitor produced by the strain of Strptomyces sp. HKI 0231. It can inhibit 3-α-hydroxysteroid dehydrogenase with IC50 of 10.5 μg/mL. It has weak antimicrobial and antifungal activity (MIC is less than 100 μg/mL).

It is a 3-α-hydroxysteroid dehydrogenase inhibitor produced by the strain of Strptomyces sp. HKI 0231. It can inhibit 3-α-hydroxysteroid dehydrogenase with IC50 of 2.5 μg/mL. It has weak antimicrobial and antifungal activity (MIC is less than 100 μg/mL).

It is a β-lactone antibiotic produced by the strain of Cephalosporium sp. It has a strong inhibitory effect on hydroxymethyl glutaryl coenzyme A (HMG-CoA) synthase.

It is an inducible nitric oxide synthase (iNOS) inhibitor produced by the strain of Streptomyces sp. AM1699. It inhibits iNOS with IC50 of 43.5 X 10-6 mol/L.

Stresgenin B is a heat-induced heat shock protein (HSP) gene expression inhibitor produced by Streptomyces sp. AS-9. It can inhibit the expression of heat-induced luciferase reporter gene, and also inhibit the synthesis of heat-induced hsp72/73, hsp90 and hsp110. It has moderate cytotoxicity to tumor cell lines such as K562, PC6, HT29, and has antimicrobial activity against Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis.

Sulphostin is a dipeptidyl peptidase IV inhibitor produced by Streptomyces sp. MK 251-43F3. Thiofostine has a strong inhibitory effect on DPP-N activity with IC50 of 6.0 ng/mL, which is 100 times stronger than the known DDP-JV inhibitor Diprotin A.

Terpendole A is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 µmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 µmol/L.

Terpendole E is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 µmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 µmol/L.

Terpendole F is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 µmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 µmol/L.

Tetracycline A is an acetylcholinesterase (AchE, EC3. 1.1.7) inhibitor produced by Aspergillus terreus. It has a strong inhibition of AchE activity with IC50 of 0.23 µmol/L.

Tetracycline B is an acetylcholinesterase (AchE, EC3. 1.1.7) inhibitor produced by Aspergillus terreus. It has a strong inhibition of AchE activity with IC50 of 0.09 µmol/L.

Tetracycline C is an acetylcholinesterase (AchE, EC3. 1.1.7) inhibitor produced by Aspergillus terreus. It has a strong inhibition of AchE activity with IC50 of 0.06 µmol/L.

Tetracycline D is an acetylcholinesterase (AchE, EC3. 1.1.7) inhibitor produced by Aspergillus terreus. It has a strong inhibition of AchE activity with IC50 of 0.42 µmol/L.