Enzyme inhibitors

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817.

It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin A to Cyclophilin is 10-20 times stronger than Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay.

It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin B to Cyclophilin is 10-20 times stronger than Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay.

It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin C to Cyclophilin is similar to Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay.

It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin D to Cyclophilin is similar to Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay.

It is a squalene synthase inhibitor produced by the strain of Schizophyllum commune SANK 17785. It inhibits squalene synthase with IC50 of 0.84 μmol/L. 1000 μg/mL of Schizostatin has no antibacterial effect on the tested bacteria, mycobacteria, yeast and mycoplasma.

It is a mammalian N-SMase inhibitor produced by the strain of Trichopeziza mollissima SANK 13892. It inhibits N-SMase with IC50 of 1.0 μmol/L.

It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain.

It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain.

It is a mammalian cell cycle inhibitor produced by the strain of Aspergillus fumigatus. 12.5 μg/mL of Spirotryprostatin B can inhibit the G2/M phase of the cell cycle in tsFT210 cells.

It is produced by the strain of Sporormiella sp. M5032. It inhibits cAMP-PDE with ID50 of 41 μg/mL. 1000 μg/mL of Sporostatin has no effect on Gram-positive bacteria, Gram-negative bacteria and Candida albicans.

It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect.

It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect.

It is a receptor antagonist produced by the strain of Stachybotrys sp. M6222. It inhibits the binding of I-ET-1 to rat ETA receptors with IC50 of 2.3 X 10-5 (mol/L). It also inhibits the binding of I-ET-1 to human ETA receptors and human ETB receptors with IC50 (mol/L) of 1.3 X 10-5 and 7.9 X 10-6, respectively.

It is a receptor antagonist produced by the strain of Stachybotrys sp. M6222. It inhibits the binding of I-ET-1 to rat ETA receptors with IC50 of 2.8 X 10-5 (mol/L). It also inhibits the binding of I-ET-1 to human ETA receptors and human ETB receptors with IC50 (mol/L) of 1.2 X 10-5 and 9.5 X 10-6, respectively.