Enzyme inhibitors

It is produced by the strain of Phellinus sp. PL3. It selectively inhibits the activity of the chitin synthase I and II with IC50 (μg/mL) of 76 and 28, respectively. It has the antifungal activity on Colletotrichum lagenarium, Pyricularia oryzae, aspergillus fumigatus and Trichophyton mentagrophytes and so on (MIC is 12.5-50 μg/mL).

It is produced by the strain of Phomopsis sp. FT-0211. Phenochalasin A (less than 20 μmol/L) can reduce the number and size of lipid droplets in macrophages without showing any cytotoxicity.

It is produced by the strain of Phomopsis sp. FT-0211. Phenochalasin A (less than 20 μmol/L) can reduce the number and size of lipid droplets in macrophages without showing any cytotoxicity.

It is produced by the strain of Penicillum griseofulvum F 1959. It can inhibit ACAT activity with IC50 of 0.8 μmol/L.

It is produced by the strain of Penicillum griseofulvum F 1959. It can inhibit ACAT activity with IC50 of 12.8 μmol/L.

It is produced by the strain of Penicillum griseofulvum F 1959. It can inhibit ACAT activity with IC50 of 16.0 μmol/L.

It is produced by the strain of Streptomyces sp. MK600-cF7. It can inhibit the activity of Proteasome with IC50 of 21.0 μg/mL.

It is produced by the strain of Streptomyces sp. MK600-cF7. It can inhibit the activity of Proteasome with IC50 of 11.0 μg/mL.

It is produced by the strain of Streptomyces sp. MK600-cF7. It can inhibit the activity of Proteasome with IC50 of 12.5 μg/mL.

It is produced by the strain of Streptomyces sp. MK600-cF7. It can inhibit the activity of Proteasome with IC50 of 7.8 μg/mL.

Cephalochromin is a calmodulin-sensitive phosphodiesterase (PDE) inhibitor isolated from the culture broth of an unidentified fungal isolate, SCF-125. It inhibited calmodulin-sensitive PDE activities with IC50 values of 40-47 nM.

Sch 420789 is a phospholipase D inhibitor produced by an unidentified fungus SCF 0953.

SNA-60-367 are a group of aromatase inhibitors produced by soil bacterium, Bacillus sp. SNA-60-367. These inhibitors are a family of acylated decapeptides that differ from each other in terms of amino acid composition and the nature of the fatty acid side chain.

SNA-4606-1 is an elaiophylin antibiotic isolated from Streptomyces sp. SNA-4606. It acts as a testosterone 5 alpha-reductase inhibitor with IC50 of 6.6 μmol/L.

SNA-4606-2 is an elaiophylin antibiotic isolated from Streptomyces sp. SNA-4606. It acts as a testosterone 5 alpha-reductase inhibitor with IC50 of 8.7 μmol/L.

SNA-4606-3 is an elaiophylin antibiotic isolated from Streptomyces sp. SNA-4606. It acts as a testosterone 5 alpha-reductase inhibitor.

SNA-8073A is an isotetracenone antibiotic isolated from the broth filtrate of Streptomyces sp. SNA-8073. It inhibited prolyl endopeptidase of Flavobacterium non-competitively with IC50 of 8.9 μmol/L.

SNF-4794-7 is produced by Chaetomella sp. It inhibits α-glucosidase with IC50 of 0.18 μg/mL.

SNF-4794-9 is produced by Chaetomella sp. It inhibits α-glucosidase with IC50 of 1.20 μg/mL.

SNF-4794-11 is produced by Chaetomella sp. It inhibits α-glucosidase with IC50 of 0.09 μg/mL.