Enzyme inhibitors

Probestin is an aminopeptidase M inhibitor produced by Str. azureus MH 663-2F6.

Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6.

Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6.

Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6.

Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nmol/L.

It is originally isolated from Aspergillus niger CFR-W-105. Nigerloxin inhibited the activity of rat lens aldose reductase (RLAR) and lipid oxidase (LOX-1) with IC50 of 69 μmol/L and 79 μmol/L, respectively.

It is originally isolated from Microsphaeropsis sp. FO-5050. 10-Norparvulenone inhibits viral Sialidase by IC50 of 21 μg/mL and inhibits influenza virus A/PR/8/34 replication in MDCK cells.

Quinolactacin A2 is the dominant analogue of a family of quinolone metabolites produced by penicillium citrinum, inhibits acetylcholinesterase and TNF production.

L-783277 is originally isolated from Phoma sp.. It inhibits MEK2 with an IC50 of 4 nmol/L.

Roselipin 1A is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L.

Roselipin 1B is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L.

Roselipin 2A is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L.

Roselipin 2B is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L.

It is produced by the strain of Polyozellus multiplex. It has the activity of inhibiting proline endopeptidase (PEP, EC 3.4.21.26) with IC50 of 1.25 μg/mL.

It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 76.80 μmol/L. It has a little inhibitory effect on other serine proteases.

It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 0.98 μmol/L. It has little inhibitory effect on other serine proteases.

It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 14.7, 2.5, 18.8, 7.2 and 18.2, respectively.

It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 10.9, 5.1, 8.4, 5.7 and 3.0, respectively. It also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50 (μg/mL) of 2.4, 1.8 and 13.9, respectively.

It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 15 μmol/L.

It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 18 μmol/L.