Enzyme inhibitors

The most fully characterised member of a family of phosphate esters of a triene antibiotic; a topoisomerase II inhibitor; selective inhibition of protein phosphatase PP2A.

Fumonisin B1 is produced by the strain of Gibberella fujikuroi and Fumarium moniliforme. It is a liver toxin, which can activate the cancer promoter and cause liver cancer. It has been reported that it is related to the occurrence of human esophageal cancer in South Africa and other places. It can also cause pig pulmonary edema, and is also the pathogenic substance of equine leukoencephalitis. Fumonisin B1 inhibits sphingosine acyltransferase.

Fumonisin B2 is a liver toxin produced by Gibberella fujikuroi and Fumarium moniliforme. It is more cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase.

Funalenone is a phenalene compound originally isolated from A. niger. It inhibits HIV-1 integrase and type I collagenase. Funalenone is also a selective inhibitor of matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM).

It is an α and β-galactosidase inhibitor.

It is produced from the Aspergillus parasiticus. Kojic Acid has anti-leptospira effect with MIC of 1-10 μg/mL. It is also a tyrosinase inhibitor, which acts as a chelating agent that inhibits the production of melanin and should help chloasma in vitro.

KRX-0601, also known as UCN-01, is a synthetic derivative of staurosporine with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting apoptosis.

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture with antineoplastic activity. It inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases.

Mniopetal A is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mniopetal B is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mniopetal C is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mniopetal D is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mniopetal E is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mniopetal F is a reverse transcriptase inhibitor produced by Mniopetalum sp. 87256.

Mumbaistatin is a glucose-3-phosphate translocase inhibitor produced by Streptomyces sp. DSM 11641.

Naphthablin is an inhibitor produced by Str. aculeolatus.

Caloporoside is a phospholipase C inhibitor produced by Caloporus dichrous. It has only weak antifungal and bacterial activity, and has the effect of selectively inhibiting phospholipase C.

Polyozellin is a prolyl endopeptidase inhibitor produced by Polyozellin multiplex.

Poststatin is a prolyl endopeptidase inhibitor produced by Str. viridochromogenes MH 534-30F3.

Pradimicin M is an antibiotic produced by Actinomadura hibisca. α-glycosidase and β-galactosidase inhibitor.