Enzyme inhibitors

Isochromophilone IV is produced by the strain of Pen. multicolor FO-3216 and FO-2328. It inhibited the ACAT of rat hepatocellular microsome with the IC50 (μmol/L) of 50.

Isochromophilone III is produced by the strain of Pen. multicolor FO-3216 and FO-2328. It inhibited the ACAT of rat hepatocellular microsome and the B-16 melanoma cell with the IC50 (μmol/L) of 50 and 36.

It is produced by the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC50 concentration of TEM-2 β-lactamase was 0.01 μg/mL.

Kodaistatin A is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 80 nmol/L.

Kodaistatin B is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 130 nmol/L.

Kosinostatin is originally isolated from Paecilomyces sp. FO-3184. It showed strong anti-gram-positive bacterial activity (MIC of 0.039 μg/mL) and moderate anti-gram-negative bacterial and yeast activity (MIC of 1.56-12.5 μg/mL). It is also poisonous to the cells of a wide variety of tumor cells with the IC50 of 0.02-0.6 μmol/L. And the IC50 of inhibition of DNA topoisomerase IIα is 3-10 μmol/L.

It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase.

It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase.

YM-170320 is a lipopeptide antibiotic produced by an unidentified fungal strain YL-03706F. It was shown to induce morphological change of colonies
in a mutant of Candida tropicalis pK233. It is a novel ergosterol biosynthesis inhibitor.

YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. QS3666. YM-254890 (1, 3, and 10 µg/kg) reduces platelet thrombus formation in a cynomolgus monkey model of femoral artery thrombosis.

YUA001 is an aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25. It has no antimicrobial activity.

ZG-1494α is a platelet-activating factor (PAF) acetyltransferase inhibitor, which is isolated from an ethyl acetate extract of a culture broth of Penicillium rubrum through bioassay guided fractionation.

Hydroxy acivicin is an antitumor agent.

UCE 6 is an antitumor metabolite with topoisomerase I mediated DNA cleavage activity.

UCF76-A is a FTase inhibitor produced by Steptomyces sp.

UCF76-B is a FTase inhibitor produced by Steptomyces sp.

UCF76-C is a FTase inhibitor produced by Steptomyces sp.

UCF116-A is a FTase inhibitor produced by Steptomyces sp.

UCF116-B is a FTase inhibitor produced by Steptomyces sp.

WA8242A is a PLA2 inhibitor consisting of A1 and A2. It is produced by Steptomyces violaceusniger No. 8242.