Enzyme inhibitors

It is produced by the strain of Duteromycete 45-93. It can inhibit TPA induced expression of k gene binding nuclear factor (NF-KB) and activator protein-1 (APT-1) mediated secreted alkaline phosphatase (SEAP), with IC50 of 4.2-9.4 mol/L and 4.2-9.4 mol/L, respectively.

It is produced by the strain of Sreptomyces melanosporofaciens M1614-43F2. It can inhibit the hemolysis phospholipase [EC 3.1.1.5] (Lyso-PL) activity. Terpentecin as substrates, it inhibits Lyso-PL, PL-A2, PL-C and PL-D with IC50 of 2.9 μg/mL, 65.0 μg/mL, 70.0 μg/mL and >100 μg/mL, respectively. Ki is 4.8 X 10-6 mol/L.

Cyclophellitol, originally isolated from a species of Phellinus mushroom, is a potent and irreversible beta-glucosidase inhibitor.

It is produced by the strain of Streptomyces lavendulae NK901093. It strongly inhibits AChE activity, it inhibits the AchE of houseflies with IC50 of 7.6 X 10-10 mol/L.

It is produced by the strain of Aspergillus sp. F70609. It can inhibit β-glucoside enzyme activity with IC50 of 75 μg/mL. It has no or only weak inhibitory effect on other glycosidases.

It is produced by the strain of Streptomyces filipinensis NR 0484. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.3 μmol/L, and the reference neomycin was 1.2 μmol/L.

It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L.

It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L.

It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L.

It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L.

It is produced by the strain of Streptomyces sp. NR0516. It selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. In addition, it has weak antifungal activity.

It is produced by the strain of Cystobacter armeniaca Cb a24, Archangium gephyra Ar 9944. It is a β-methoxy acrylic acid (MOA) inhibitor. Cyrmenin A inhibits NADH oxidation of bovine heart submitochondrial particles with IC50 of 27 ng/mL. The mechanism is to block the bc1 phase of electron transport in the respiratory chain.

It is produced by the strain of Cystobacter armeniaca Cb a24, Archangium gephyra Ar 9944. It is a β-methoxy acrylic acid (MOA) inhibitor. Cyrmenin B1 inhibits NADH oxidation of bovine heart submitochondrial particles with IC50 of 41 ng/mL. The mechanism is to block the bc1 phase of electron transport in the respiratory chain.

It is produced by the strain of Cystobacter armeniaca Cb a24, Archangium gephyra Ar 9944. It is a β-methoxy acrylic acid (MOA) inhibitor. Cyrmenin B2 inhibits NADH oxidation of bovine heart submitochondrial particles with IC50 of 159 ng/mL. The mechanism is to block the bc1 phase of electron transport in the respiratory chain.

It is produced by the strain of Streptomyces sp. It is a catechole-O-methyltransferase inhibitor (IC50 is 0.2 g/mL).

It is produced by the strain of Micromonosporaechinospora MG199-fF35. It has inhibitory effects on β-lactamase, DNA enzyme and Topoisomerase I.

It is produced by the strain of Micromonosporaechinospora MG199-fF35. It is a β-lactamase inhibitor.

It is produced by the strain of Streptomyces diastatochromogenes AB 1691Q-321 and AB 1711J-452. It's an immunosuppressant.

It is produced by the strain of Streptomyces diastatochromogenes AB 1691Q-321 and AB 1711J-452. It's an immunosuppressant.

It is produced by the strain of Streptomyces diastatochromogenes AB 1691Q-321 and AB 1711J-452. It has weak anti-bacterial and anti-aspergillus Niger activity, and shows immunosuppressive effect in the mouse popliteal node model.