Enzyme inhibitors

It is produced by the strain of Streptomyces sp. Tu 4128. Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA). It is an important target in oncology.

It is produced by the strain of Streptormyces venezuelae. Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

It is produced by the strain of Bipolaris zeicila. Cochlioquinone A inhibited DGAT with IC50 of 5.6 μg/mL.

It is produced by the strain of Streptomyces alanosinicus. It can inhibit adenine biosynthesis, resist yeast, dysentery morphosis, trichomonas vaginalis, inhibit neurotropic vaccinia virus and poliomyelitis virus, and also inhibit fibrosarcoma of transplanted ground mice.

It is produced by the strain of Streptomyces sp. Chitinase specific inhibitor.

It is produced by the strain of Humicola sp. FO-2942. It inhibits DGAT activity, and the IC50 of rat liver microsomes DGAT is 10.1 X 10-6mol/L. It also inhibits triacylglycerol formation in intact Raji cells.

It is produced by the strain of Humicola sp. FO-2942. It inhibits DGAT activity, and the IC50 of rat liver microsomes DGAT is 17.5 X 10-6 mol/L. It also inhibits triacylglycerol formation in intact Raji cells.

It is produced by the strain of Streptomyces coerulescens. It has a competitive binding to the cardiac natriuretic peptide (ANF) receptor.

It is produced by the strain of Penicillum sp. FO-3929. It can inhibit PFTase. IC50 is 24.9 μmol/L.

Cytosporin A is an angiotensin II receptor antagonist produced by Cytospora sp. Cytosporin A selectively inhibits the binding of angiotensin II to the AT2 site of the receptor with IC50 of 1.5-3.0 mol/L (0.5 to 1 μg/mL).

Cytovaricin B is a Janus kinase-signal transducer and activation protein (JAK-STAT) inhibitor produced by Streptamyces torulosus 3197-GM1.

Deacetylravidomycin M is an interleukin-4 signaling inhibitor produced by Streptomyces sp. WK-6326. It has little antibacterial activity, but it can inhibit the expression of CD23 induced by interleukin-4 in U937 cells, and has no cytotoxicity.

Decarestrictin B is a cholesterol biosynthesis inhibitor with a Decanolide structure produced by Penicillum sunplicissimum and Pen. corylophilufn.

Dehydrophenylahistin are two dehydrogenated products produced by the enzymatic conversion of the fungal metabolite (-)-phenylhistidine [(-)-phenylahistin] through the cell-free extract of Streptomyces albulus KO23. It can inhibit the first lysis of sea urchin embryos.

Delaminomycin A is an extracellular Matrix receptor antagonist and immunomodulator produced by Streptomyces albulus MJ202-72F3. It inhibits cell adhesion ECM (Extracellular matrix), reduces immune response activity, and inhibits Gram-positive bacteria.

Delaminomycin B is an extracellular Matrix receptor antagonist and immunomodulator produced by Streptomyces albulus MJ202-72F3. It inhibits cell adhesion ECM (Extracellular matrix), reduces immune response activity, and inhibits Gram-positive bacteria.

Delaminomycin C is an extracellular Matrix receptor antagonist and immunomodulator produced by Streptomyces albulus MJ202-72F3. It inhibits cell adhesion ECM (Extracellular matrix), reduces immune response activity, and inhibits Gram-positive bacteria.

Epivaliolamine is a pseudo-aminosugars produced by Streptomyces hygroscopicus sub sp. limoneue. It has a very weak inhibitory substance α-Glucosidase activity.

Epostatin is a dipeptidase II inhibitor produced by Streptomyces sp. MJ 995-OF5. It can inhibit DPP-II with an IC50 of 9.6 μg/mL, and has a weak inhibitory effect on other dipeptidase peptidases.

Epoxyquinol A is an anti-angiogenic substance produced by a fungus. An inhibitor of the transcription factor NF-KB.