Enzyme inhibitors

It is produced by the strain of Penicillum aurantiogriseum Die-rckx TP-F0213. It can inhibit Colon cancer DLD-1 Cells that do not depend on adherent growth with IC50 of 1.2 μg/mL, and cells that depend on adherent growth with IC50 of 40 μg/mL.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.41 mmol/L.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.12 mmol/L.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.22 mmol/L.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.37 mmol/L.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.33 mmol/L.

It is produced by the strain of Streptomyces violaceus 2448-SVT2. It acts as an antioxidant and GMP phosphodiesterase inhibitor. IC50 is 0.42 mmol/L.

It is produced by the strain of Actinomyces sp. Lu 9419. Cetoniacytone A has weak activity against gram-positive and negative bacteria. It can inhibit the growth of HEPG2 and MCF7 human tumor cell lines. GI50 is 3.2 ㎛ol/L.

It is produced by the strain of Actinomyces sp. Lu 9419. It can inhibit the growth of HEPG2 and MCF7 human tumor cell lines. GI50 is 4.4 ㎛ol/L.

It is produced by the strain of Chaetomium atrobrunneum F449. Chaetoatrosin inhibits chitin synthase of IC50 of 104 ㎍/mL. Chaetoatrosin has antifungal activity including Pyricularia oryzae, Botrytis cinerea, Cryptococcus neoformans, Trichophyton mentagrophytea and so on.

Acarbose is an inhibitor of alpha-glucosidase isolated from Actinoplance sp., used to treat type 2 diabetes.

Acarbose is an acyl-CoA isolated from Pseudomonas species. A92. In the presence of oxidized low-density lipoprotein in macrophages J744, the synthesis of cholesterol enzymes is inhibited, with an IC50 of 45 µmol/L, and the IC50 for inhibiting ACAT in rat liver microsomes is 120 µmol/L. Inhibition of ACAT is non-competitive Sexual.

Acivicin is an isoxazole antibiotic isolated from Streptomyces. sviceus. Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively) as a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells. Acivicin is an inhibitor of GGT used for solid tumor research

Adipostatin is a glycerol-3-phosphate dehydrogenase inhibitor produced in Streptornyces cyaneus 2299-SVI. Adipostatin A is an inhibitor of glycerol-3-phosphate dehydrogenase. It prevents triglyceride accumulation in 3T3-L1 cells when applied at 5-7.5 µM. Adipostatin A is cytotoxic against fibroblast carcinoma KB cell lines with an IC50 value of 10.6 µM.

9-β-D-Arabinof uranosyladenine is a nucleoside antibiotic produced by Streptomyces antibioticusm and Str. herbaceusm. It has a strong weeding effect on a variety of monocotyledonous and dicotyledonous plants.

Arphamenine A is an enzyme inhibitor produced by Chromobacteriuin violaceum HMG361-CF4. It can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and IMC cancer.

Arphamenine B is an enzyme inhibitor produced by Chromobacteriuin violaceum HMG361-CF4. It can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and IMC cancer.

Asterric acid is an Endothelin (ET) binding inhibitor produced by Aspergillus sp.

Bisucaberin is a siderophore anti-tumor antibiotic produced by the monosporium Alteromonas haloplanktis SB-1123 obtained from deep sea sludge. It can bind high iron ions and has a specific inhibitory effect on tumor cell DNA synthesis.

Calphostin C is a protein kinase C inhibitor produced by cladosporium cladosporioides.