Enzyme inhibitors

Ashimycin B is an aminoglycoside antibiotic produced by Streptomyces griseus FT3-4. It has a broad-spectrum antibacterial activity, but is lower than streptomycin.

Asperaldin is an aldose reductase (ECLLL21) inhibitor produced by Aspergillus niger CFR-1046.

Asterriquinone SU5500 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase.

Asterriquinone SU5228 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase.

Aurachin C is a quinoline compound produced by Stigmatella aurantiaca Sg al5. It has the activity of inhibiting gram-positive bacteria and a few yeasts and filamentous fungi, and can block the NADH oxidation of bovine heart microsomal particles.

Aurachin D is a quinoline compound produced by Stigmatella aurantiaca Sg al5. It has the activity of inhibiting gram-positive bacteria and a few yeasts and filamentous fungi, and can block the NADH oxidation of bovine heart microsomal particles.

Bergofungin B is a Peptaibols compound produced by Emericellopsis donezkii HKI 0059. It has anti-fungal activity such as Sporibolomy-ces salmonicolor and PenicilltiTn fiotatum. It also moderately inhibits prolyl endopeptidase activity.

Bergofungin C is a Peptaibols compound produced by Emericellopsis donezkii HKI 0059. It has anti-fungal activity such as Sporibolomy-ces salmonicolor and PenicilltiTn fiotatum. It also moderately inhibits prolyl endopeptidase activity.

Bergofungin D is a Peptaibols compound produced by Emericellopsis donezkii HKI 0059. It has anti-fungal activity such as Sporibolomy-ces salmonicolor and PenicilltiTn fiotatum. It also moderately inhibits prolyl endopeptidase activity.

Bisabosqual A is a squalene synthase inhibitor produced by Stach-ybotrys sp. RF-7260. Bisabosqual A has broad-spectrum antifungal activity.

Bisabosqual B is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia. Bisabosqual B Antifungal activity is weak.

Bisabosqual C is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia.

Bisabosqual D is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia.

5-Bromoochrephilone is one of the products of Penicillum multicolor FO-2338 in broth containing potassium bromide. It has strong inhibitory activity on gP120-CD4 binding.

Calphostin A is a protein kinase C inhibitor produced by cladosporium cladosporioides.

Calphostin B is a protein kinase C inhibitor produced by cladosporium cladosporioides.

Calphostin D is a protein kinase C inhibitor produced by cladosporium cladosporioides.

Aureoquinone is produced by the strain of Aureobasidium sp. The IC50 (μg/mL) for inhibiting the activity of protease, including trypsin, papain, thermophilic protease, collagenase and pound-protease are 11.4、14.5、17.8、7.1、and 8.7 respectively.

Australifungin is produced by the strain of Sporormiella australis. As an inhibitor of Shinganine n-acyl-transferase, it has strong antifungal activity, with MIC of 0.015-0.5 μg/mL for candida, cryptococcus neoforme, saccharomyces cerescens and other fungi, and 0.125 ~ 1μg/ mL for aspergillus. Australian fennetol has a low antifungal effect.

Azepinomycin is produced by the strain of Streptomyces toyokaensis MF71803. It can inhibit Guanase and tumor cell.