Enzyme inhibitors

Acetophthalidin is a mammalian cell cycle inhibitor isolated from Penicillum sp. BM 923.

5-N-Acetylardeemin is a heterocyclic compound isolated from Aspergillus fischeri var.brasiliensis AB 1826 M-35. 5-N-Acetylardeemin can enhance the cytotoxicity of the antineoplastic drug vincristine to multi-drug resistant human tumor cells.

Acetyl 1-L-leucyL-L-arginine is a lactone compound isolated from the Bacterium sp. BMG520-yF2. Acetyl 1-L-leucyL-L-arginine has the activity of inhibiting dipeptidyl aminopeptidase Ⅲ.

Adechlorin is a nucleoside compound produced from Actinomadura sp. OMR-37. Adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties.

Adecypenol is an adenosine deaminase inhibitor produced from Streptomyces sp. OM-3223.

Adenophostin A is an inositol-1,4,5-triphosphate receptor antagonist produced from Penicillurn brevicompactum SANK 11991. Adenophostin is a potent inositol trisphosphate (IP3) receptor agonist.

Adenophostin B is an inositol-1,4,5-triphosphate receptor antagonist produced from Penicillurn brevicompactum SANK 11991. Adenophostin is a potent inositol trisphosphate (IP3) receptor agonist.

Adiposin 1 is a metabolite of Streptomyces calvus TM-521 and Str.sp.A2396. Adiposin has anti-gram-positive bacteria, negative bacteria, plant pathogenic fungi activity, and has a strong inhibitory effect on alpha-amylase.

Adiposin 2 is a metabolite of Streptomyces calvus TM-521 and Str.sp.A2396. Adiposin has anti-gram-positive bacteria, negative bacteria, plant pathogenic fungi activity, and has a strong inhibitory effect on alpha-amylase.

Adxanthromycin A, a new inhibitor of ICAM-1/LFA-1 mediated cell adhesion from Streptomyces sp. NA-148.

Adxanthromycin B, a new inhibitor of ICAM-1/LFA-1 mediated cell adhesion from Streptomyces sp. NA-148.

Anthrotainin is a substance P (Substance P, SP) binding inhibitor produced by Gliocladium catenulatum.

Aphidicolin-17-monoacetate is an antibiotic produced by Phoma betae PS-13, which inhibits DNA polymerase and interferes with root growth.

Questiomycin A is a phenoxazine antibiotic produced by several streptomyces species and some fungi and bacteria, exhibiting weakly activity against bacteria, fungi, plants and tumour cell lines. It inhibits aromatase and sulfatases, stimulates cell growth and turnover in vitro.

Cyclo (-Leu-Pro) is a cyclic dipeptide containing leucine and proline.

Sulbactam is an irreversible inhibitor of β-lactamase. It binds to the enzyme and does not allow it to degrade the antibiotic.

Sulopenem is a penem antibiotic and a β-lactamase inhibitor produced by Penicillium. Sulopenem showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia.

K252a, an analog of staurosporine, has been found to be a protein kinase inhibitor and exhibit antitumor activity at some extent.

Staurosporine, also known as antibiotic AM-2282 or STS, is a broad spectrum protein kinase inhibitor produced by Streptomyces sp. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM). Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive.

The citrate salt form of Ixazomib which is a proteasome inhibitor. It is undergoing a rollover Phase II trial against multiple myeloma, amyloidosis and lymphoma in sorts of countries. IC50 = 3.4 nM.