Mycotoxins

Mycotoxins

Catalog Product Name / CAS / Description Structure
BBF-04088

γ-Mangostin (31271-07-5)

Inquiry

gamma-Mangostin isolated from the fruit of Garcinia cambogia is an HIV protease inhibitor. gamma-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).

BBF-05733

N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic that could be a potential cytotoxic DNA-binding agent in antibody-drug-conjugation (ADC). Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis.

BBF-03980

L-Penicillamine is a medication primarily used for the treatment of Wilson's disease.

BBF-05734

Irofulven (158440-71-2)

Inquiry

Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle.

BBF-03858

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

BBF-04462

Aflatrem (70553-75-2)

Inquiry

Aflatrem is the secondary metabolite of Aspergillus flavus. It is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems at low dose. It potentiates the gamma-aminobutyric acid (GABA)-induced chloride current. It is a tremorgenic mycotoxin with acute neurotoxic effect.

BBF-04461

β-Aflatrem (144446-23-1)

Inquiry

β-Aflatrem is a class of structurally-diverse secondary metabolites isolated from Aspergillus flavus. It is a mycotoxin that exhibits insecticidal activity.

BBF-01828

Deoxynivalenol (51481-10-8)

Inquiry

Deoxynivalenol is a type B trichothecene, an epoxy-sesquiterpenoid. This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects. It inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA, contributing to immunotoxicity.

BBF-05778

DM4 (796073-69-3)

Inquiry

DM 4 is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.

BBF-05777

Mertansine (139504-50-0)

Inquiry

Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine.

BBF-05783

MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate.

BBF-05782

MMAE (474645-27-7)

Inquiry

Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.

BBF-00588

Brevetoxin A (98112-41-5)

Inquiry

Brevetoxin A is a polyacyl toxoid produced by Ptychodiscus brevis (Gymnodiniuin bervis). It has a strong effect of activating cell membrane sodium channels, and Tetrodotoxin can counteract its activity.

BBF-05667

Deoxyradicinol (97588-11-9)

Inquiry

Deoxyradicinol, a novel compound with phytotoxic activity, is isolated from liquid cultures of Alternaria helianthi.

BBF-04012

T2 Toxin Triol (97373-21-2)

Inquiry

The 100 ppm acetonitrile solution of T2 Triol toxin, a kind of type-A trichothecene mycotoxin, could be used as standard solution.

BBF-03843

Bithionol (97-18-7)

Inquiry

Bithionol is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models. It caused dose-dependent cytotoxicity against all ovarian cancer cell lines.

BBF-04113

Microcystin-LA (96180-79-9)

Inquiry

Microcystin is a class of cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA is an analog of the major microcystin-LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with IC50 value of 0.3 nM.

BBF-04670

Ascochin (935699-58-4)

Inquiry

Ascochin is a fungal metabolite found in Ascochyta, which has antifungal, antibacterial and phytotoxic activities.

BBF-03682

MT 81 (93513-59-8)

Inquiry

MT 81 is a plant toxin that comes from Penicillum nigricans. It has anti-Gram-positive bacteria activity.

BBF-00112

Asperlicin (93413-04-8)

Inquiry

Asperlicin is a non-peptide cholecystokinin (Cholecystokinin, CCK) produced by Aspergillus alliaceus. It has the effect of antagonizing CCK. A and its derivatives are promising for the treatment of ulcers and pancreatic tumors.

BOC Sciences has been committed to providing customers with a rich variety of mycotoxins.

Fungi are higher organisms among microorganisms. They are microorganisms that have cell walls, no chlorophyll, no roots, leaves or stems, and survive by saprophytic or parasitic methods, and can reproduce sexually or asexually. Fungi are used to process food. However, under certain circumstances, fungi can cause food to spoil. Some fungi can cause human diseases as pathogens. The metabolites of fungi-mycotoxins can also cause harm to humans and animals.

Mycotoxin is a secondary metabolite produced by certain fungi (such as Aspergillus, Fusarium, etc.). Feed or food in feed or food can cause acute or chronic poisoning of humans and animals, and damage the body's organs and tissues. Mycotoxins endanger the growth and reproduction performance of animals, humans and crops, and endanger health. Mycotoxins are ubiquitous in the environment around us.

Classification of Mycotoxins

There are many types of mycotoxins, and hundreds of mycotoxins have been found. According to chemical structure, mycotoxins include trichothecenes, zearalenone, butenolides, etc. According to the source, mycotoxins include aflatoxin, ochratoxin, sterigmatocystin, islandin, patulin, citrinin, and fusarium mycotoxins.

Characteristics of Mycotoxins

Mycotoxins are a large family with a molecular weight of 200-500 kD with different chemical properties.

  • High efficiency: very low concentration can produce obvious toxicity
  • High stability: small molecule compounds, stable properties, high temperature resistance, acid resistance
  • Enrichment: resistance to chemical biological agents and physical inactivation
  • Specificity: the molecular structure is different, the toxicity is quite different
  • Synergy: The combined effect of multiple mycotoxins is higher than the cumulative addition of the effects of a single mycotoxin.

Application Examples of Mycotoxins

Aflatoxin is a strong carcinogen and is related to the onset of liver cancer. The erythrenone in common corn has an estrogen-like effect. The ergotoxine secreted by clavieps purpurea has a strong effect of constricting arteries and blood vessels, resulting in limb necrosis. However, certain ergot preparations can be used as uterine contractors.

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