Mycotoxins

It is a mycotoxin isolated from Emericella violacea and Aspergillus spp. It has weak activity against Gram-positive bacteria, Gram-negative bacteria, fungi and yeast.

Deoxyradicinol, a novel compound with phytotoxic activity, is isolated from liquid cultures of Alternaria helianthi.

Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.

Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43.

Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs.

Ansamitocin derivative TN-006 is a derivative of Ansamitocin, a family of polyketide antibiotics comprising a naphthalene/benzene or napthaquinone/benzoquinone ring system bridged at nonadjacent positions by an aliphatic chain.

Dov-Val-Dil-OH is an intermediate of dolastoxin, a cytotoxic liner peptide produced by Dolabbella auriclaria which exhibits potent antitumor activity.

Exotoxin A is an exotoxin derived from Pseudomonas aeruginosa. It was shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2.

Hydrolyzed Fumonisin B2 is a metabolite of Fumonisin B2, a mycotoxin produced by mold associated with corn.

Hydrolyzed Fumonisin B1 is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1. Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase.

15-Acetyl-DON is a mycotoxin produced by the fungi Fusarium culmorum and Fusarium graminearum. It can inhibit protein synthesis.

Tenuazonic Acid Copper Salt is an alternaria mycotoxin, found in common edible crops. It inhibits protein synthesis in fibroblasts.

Aflatoxin Q1 is a metabolite of Aflatoxin B1. It is created in human body as a in-vivo detoxification process of Aflatoxin B1.

It is a natural mycotoxin that has cytotoxic activity against select cancer cell lines. It has been shown to activate the heat shock response, block TGF-β signaling, and scavenge superoxide anions.

Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer.

MMAF Hydrochloride, a synthetic antineoplastic agent, is a tubulin polymerization inhibitor that inhibits cell division by blocking the polymerization of tubulin. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate in the synthesis of Exatecan, Irinotecan and Camptothecin analogs.

It is an impurity of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer.

Fmoc-3VVD-OH is a cleavable ADC linker used to synthesize antibody-drug conjugations (ADCs).

N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine, a microtubule inhibitor, is a PEG linker used in antibody-drug-conjugation (ADC).