Mycotoxins

TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr.

Strobilurin O is a compound produced by Mycena galericularata. It has nematicidal activity, strong cytotoxicity to HeLa-S3, with IC50 of 0.02-0.06 μg/mL. It also has anti-fungal activity such as Pyricularia oryzae, with MIC 12.5 μg/mL.

Strobilurin P is a compound produced by Mycena galericularata. It has nematicidal activity, strong cytotoxicity to HeLa-S3, with IC50 of 0.02-0.06 μg/mL. It also has anti-fungal activity such as Pyricularia oryzae, with MIC 12.5 μg/mL.

Tetrazomine is an antibiotic produced by Saccharothrix mulabilis subsp. chichijimaensis. It is active against gram-positive bacteria, gram-negative bacteria and mycobacteria. It has cytotoxic activity and inhibits lymphoid leukemia L1210 and leukemia P388 with IC50 of 0.047 and 0.0140 μg/mL, respectively.

Thiocoraline is a peptide antibiotic produced by Micromonospora sp. L-13-ACM2-092. It has strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria activity. The effect of inhibiting RNA synthesis is stronger than that of inhibiting DNA synthesis. Cytotoxic activity.

A82548A is a macrolide antibiotic containing spiroacetal produced by Streptomyces diastatochromogenes.

AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJ9561. It has cytotoxic activity with IC50 of 0.88 µmol/L and 1.63 µmol/L for Jorkat and P388 cells, respectively. Its mechanism of action is the same as that of UK-1, which can inhibit DNA topoisomerase U.

BE-19412A is an antitumor antibiotic extracted from the culture medium of Streptomyces sp. A19412. It is toxic to mouse and human tumor cells such as P388, Ehrlich, DLD-1, PC-13, MKN-45 and Colon 26, with IC50 of 0.9-5.4 μg/mL, and can prolong the survival time of CDF1 mice with Ehrlich cancer.

BE-19412B is an antitumor antibiotic extracted from the culture medium of Streptomyces sp. A19412. It is toxic to mouse and human tumor cells such as P388, Ehrlich, DLD-1, PC-13, MKN-45 and Colon 26, with IC50 of 0.9-5.4 μg/mL, and can prolong the survival time of CDF1 mice with Ehrlich cancer.

BE-29602 is a papulacandin antibiotic produced by Fusarium sp. F296O2. It has activity against Candida, Saccharomyces cerevisiae and other fungi, with an MIC of 0.20-0.7 μg/mL. It is cytotoxic and has an IC50 of 21 μg/mL to P388 murine leukemia cells.

BE-52400A is a cytotoxicity produced by Streptomyces sp. A52400. It has anti-proliferative effect on mouse tumor cell lines such as P388 leukemia and colon 26 colon and human tumor cell lines such as DLD1 (colon), PC-13 (lung), MKN-45 (stomach), etc., with IC50 of 6.1, 2.1, 0.47, 3.9, 0.88 μg/mL.

BE-52400B is a cytotoxicity produced by Streptomyces sp. A52400. It has anti-proliferative effect on mouse tumor cell lines such as P388 leukemia and colon 26 colon and human tumor cell lines such as DLD1 (colon), PC-13 (lung), MKN-45 (stomach), etc., with IC50 of 1.1, 3.4, 0.69, 2.6, 2.9 μg/mL.

BE-54238A is a cytotoxic agent produced by Streptomyces sp. A54238. It has anti-proliferative effects on tumor cells such as P388, DLD4, PC-13, MKN-45, colon 26, etc., with IC50 of (μg/mL) 9.1, 3.5, 11.3, 8.1, 8.6.

BE-54238B is a cytotoxic agent produced by Streptomyces sp. A54238. It has anti-proliferative effects on tumor cells such as P388, DLD4, PC-13, MKN-45, colon 26, etc., with IC50 of (μg/mL) 58.2, 10.1, 53.2, 45.6, 20.5.

BMS-192548 is a neuropeptide Y (NPY) receptor binding inhibitor produced by Aspergillus niger WB2346. It also has weak cytotoxicity, with an IC50 of 240 µmol/L for murine tumor cells M-109.

(E)-Pterulinic acid is a Coenzyme I: Coenzyme Q oxidoreductase inhibitor produced by Pterula sp. 82168. It has anti-yeast and filamentous fungus effect and has cytotoxic activity.

(Z)-Pterulinic Acid is a Coenzyme I: Coenzyme Q oxidoreductase inhibitor produced by Pterula sp. 82168. It has anti-yeast and filamentous fungus effect and has cytotoxic activity.

NT-2 is a toxin produced by Fusarium sporotrichioides M-1.

NT-3 is a toxin produced by Fusarium sporotrichioides M-1.

Urdamycin G is a platelet aggregation inhibitor from Streptomyces sp. OM-4842. It inhibits platelet aggregation induced by ADP, arachidonic acid, PAF and collagen with MIC of 12.5, 5.0, 25.0, >25.0 µg/mL, respectively. It also exhibits cytotoxicity.