Metabolites-BOC Sciences

10'-Desmethoxystreptonigrin

10'-Desmethoxystreptonigrin - CAS 136803-89-9

Catalog number: BBF-01834

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Catalog Number BBF-01834
CAS 136803-89-9
Description It is a close analogue of streptonigrin produced by selected streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active than streptonigrin. It has potent and broad spectrum antibacterial and antitumour activity.
Molecular Formula C24H20N4O7
Molecular Weight 476.44
Antibiotic Activity Spectrum Neoplastics (Tumor); Bacteria
Synonyms 2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3-methoxyphenyl)-3-methyl-; 10-Desmethoxystreptonigrin
IUPAC Name 5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3-methoxyphenyl)-3-methylpyridine-2-carboxylic acid
Canonical SMILES CC1=C(C(=C(N=C1C(=O)O)C2=NC3=C(C=C2)C(=O)C(=C(C3=O)N)OC)N)C4=C(C(=CC=C4)OC)O
InChI InChI=1S/C24H20N4O7/c1-9-14(10-5-4-6-13(34-2)20(10)29)15(25)19(28-17(9)24(32)33)12-8-7-11-18(27-12)22(31)16(26)23(35-3)21(11)30/h4-8,29H,25-26H2,1-3H3,(H,32,33)
InChI Key ULSNCNUVHUNMCF-UHFFFAOYSA-N
Boiling Point 683.6°C at 760 mmHg
Purity >95% by HPLC
Density 1.55 g/cm3
Solubility Soluble in Ethanol, Methanol, DMF, DMSO; Poorly soluble in Water
Appearance Red Brown Solid
Storage Store at -20°C
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