10-Dihydrosteffimycin B
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| Category | Antibiotics |
| Catalog number | BBF-01417 |
| CAS | 75086-97-4 |
| Molecular Weight | 590.57 |
| Molecular Formula | C29H34O13 |
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Description
It is produced by the strain of Chaetomium sp. BB 427. 10-Dihydrosteffimycin B has anti-gram-positive bacterial activity.
Specification
| Synonyms | 3,4,10,12-Tetrahydroxy-2,8-dimethoxy-3-methyl-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 6-deoxy-2,4-di-O-methylhexopyranoside |
| IUPAC Name | 4,6,9,10-tetrahydroxy-7-(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)oxy-2,8-dimethoxy-9-methyl-8,10-dihydro-7H-tetracene-5,12-dione |
| Canonical SMILES | CC1C(C(C(C(O1)OC2C(C(C(C3=CC4=C(C(=C23)O)C(=O)C5=C(C4=O)C=C(C=C5O)OC)O)(C)O)OC)OC)O)OC |
| InChI | InChI=1S/C29H34O13/c1-10-23(38-4)22(34)25(39-5)28(41-10)42-24-18-14(26(35)29(2,36)27(24)40-6)9-13-17(21(18)33)20(32)16-12(19(13)31)7-11(37-3)8-15(16)30/h7-10,22-28,30,33-36H,1-6H3 |
| InChI Key | HLDJDCWKEYDIPB-UHFFFAOYSA-N |
Properties
| Appearance | Crystalline |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 770.5°C at 760 mmHg |
| Density | 1.52 g/cm3 |
Reference Reading
1. Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B
P F Wiley, D W Elrod, J M Slavicek, V P Marshall J Antibiot (Tokyo). 1980 Aug;33(8):819-23. doi: 10.7164/antibiotics.33.819.
It has been shown that steffimycin (1) and steffmycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH, and enzyme concentration have been determined for the conversion of 2 to 4. The biochemical conversion of 2 has been found to be TPNH linked.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
