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15-Deoxy-15-oxolankamycin

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-01354
CAS
Molecular Weight 830.99
Molecular Formula C42H70O16

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Streptomyces violaceoniger. 15-Deoxy-15-oxolankamycin has a weak anti-gram-positive effect, with anti-Staphylococcus aureus activity equal to half that of Lankamycin.

  • Properties
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Appearance Colorless Acicular Crystalline
Antibiotic Activity Spectrum Gram-positive bacteria
Melting Point 139-141°C
1. Biotransformation of lankamycin, darcanolide, and 11-acetyllankolide by a blocked mutant of the erythromcyin producing organism Streptomyces erythreus
A W Goldstein, R S Egan, S L Mueller, J R Martin, W Keller-Schierlein J Antibiot (Tokyo). 1978 Jan;31(1):63-9. doi: 10.7164/antibiotics.31.63.
The biotransformation of lankamycin and congeners darcanolide and 11-acetylankolide by a blocked mutant of the erythromycin-producing organism Streptomyces erythreus, which cannot synthesize erythromycin without supplementation with erythromycin precursors, was investigated. Darcanolide and 11-acetyllankolide were converted into the corresponding 15-deoxy-15-oxo derivatives. Lankamycin was transformed to 15-deoxy-15-oxolankamycin, 4''-deacetyl-15-deoxy-15-oxolankamycin and 3'-de-O-methylankamycin. None of the derivatives possessed high antimicrobial activity.

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