17-AAG
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Category | Antibiotics |
Catalog number | BBF-04479 |
CAS | 75747-14-7 |
Molecular Weight | 585.69 |
Molecular Formula | C31H43N3O8 |
Purity | >98% |
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Capabilities & Facilities
Fermentation Lab
4 R&D and scale-up labs
2 Preparative purification labs
Fermentation Plant
Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs.
- Specification
- Properties
- Reference Reading
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Related CAS | 911710-03-7 (hydrochloride) |
Synonyms | Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG |
Storage | Store at -20°C |
IUPAC Name | [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate |
Canonical SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC |
InChI | InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1 |
InChI Key | AYUNIORJHRXIBJ-TXHRRWQRSA-N |
Source | Semisynthetic Derivate of Geldanamycin |
Appearance | Solid |
Antibiotic Activity Spectrum | Neoplastics (Tumor) |
Boiling Point | 797.8±60.0°C (Predicted) |
Melting Point | 205-210°C |
Flash Point | 436.3°C |
Density | 1.21 g/cm3 |
Solubility | Soluble in DMSO, Ethanol |
LogP | 3.95760 |
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
