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19αH-Lupan-3β-ol, 20,28-epoxy-, acetate

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19αH-Lupan-3β-ol, 20,28-epoxy-, acetate
Category Others
Catalog number BBF-05110
CAS 26803-59-8
Molecular Weight 484.75
Molecular Formula C32H52O3

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

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IUPAC Name (1S,4aS,6aR,6bR,8aR,10S,12aR,12bR,14aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyloctadecahydro-2H,4H-1,4a-ethanophenanthro[2,1-f]isochromen-10-yl acetate
Boiling Point 526.7±23.0°C (Predicted)
Melting Point 276-280°C
Density 1.06±0.1 g/cm3 (Predicted)
1. Cytotoxic effect of triterpenoids from the root bark of Hibiscus syriacus
Li-Shian Shi, Chao-Hsuan Wu, Te-Chun Yang, Chen-Wen Yao, Hang-Ching Lin, Wen-Liang Chang Fitoterapia. 2014 Sep;97:184-91. doi: 10.1016/j.fitote.2014.05.006. Epub 2014 May 23.
In this study, 4 new triterpenoids-3β- acetoxy-olean-11-en,28,13β-olide (1), 3β- acetoxy-11α,12α-epoxy-olean-28,13β-olide (2), 19α-epi-betulin (3), and 20, 28-epoxy-17β,19β-lupan-3β-ol (4)-and 12 known compounds, were isolated from the root bark of Hibiscus syriacus L. by using acetone extraction. Their structures were characterized by extensive spectroscopic analysis. To investigate cytotoxicity, A549 human lung cancer cells were exposed to the extract and the compounds identified from it. Significantly reduced cell viability was observed with betulin-3-caffeate (12) (IC50, 4.3 μM). The results of this study indicate that betulin-3-caffeate (12) identified from H. syriacus L. may warrant further investigation for potential as anticancer therapies.

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