(3α,7α)-17-Norkaurane-3,7-diol

(3α,7α)-17-Norkaurane-3,7-diol

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(3α,7α)-17-Norkaurane-3,7-diol
Category Others
Catalog number BBF-05592
CAS 81727-21-1
Molecular Weight 292.46
Molecular Formula C19H32O2

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Specification

Synonyms 17-Norkaurane-3,7-diol, (3alpha,7alpha)-; 17-Norkaurane-3,7-diol, (3α,7α)-
IUPAC Name (3R,4aS,6R,6aS,9S,11aS,11bR)-4,4,11b-trimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalene-3,6-diol

Reference Reading

1. Bile acids. 38. Conversion of 5 -cholestane-3 ,7 -diol to allo bile acids by the rat
B W Noll, E A Doisy Jr, W H Elliott J Lipid Res. 1973 Jul;14(4):385-90.
5alpha-[4-(14)C, 3alpha-(3)H]Cholestane-3beta,7alpha-diol was prepared from individual samples of 5alpha-[3alpha-(3)H]cholestane-3beta,7alpha-diol and 5alpha-[4-(14)C]cholestane-3beta,7alpha-diol, each derived from 3beta-acetoxycholest-5-en-7-one. Bile was collected for 11 days from adult male rats, with cannulated bile ducts, that had received intraperitoneally 0.90-0.92 mg of the doubly labeled diol. Bile from the first 10 hr, containing 63% of the administered (14)C and 6% of the (3)H, was hydrolyzed, and the bile acids were separated by acetic acid partition chromatography. Allochenodeoxycholic and allocholic acids contained at least 20.6% and 48.6%, respectively, of the (14)C retained in the biliary acids. Small amounts of (14)C (2.5% and 1.9%, respectively) were present in the 3beta isomers of these acids, but the tritium content totaled more than half of that found in the bile acid fraction. No evidence was obtained for presence of the extensive quantities of the allomuricholates.

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