3',8-Dihydroxy-4',6,7-trimethoxyisoflavone
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| Category | Enzyme inhibitors |
| Catalog number | BBF-01151 |
| CAS | 57800-11-0 |
| Molecular Weight | 344.32 |
| Molecular Formula | C18H16O7 |
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Description
It is produced by the strain of Streptomyces sp. It is a catechole-O-methyltransferase inhibitor (IC50 is 0.2 g/mL).
Specification
| Synonyms | 6,7-Dimethoxy-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran; 4H-1-Benzopyran, 6,7-dimethoxy-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)- |
| IUPAC Name | 8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxychromen-4-one |
| Canonical SMILES | COC1=C(C=C(C=C1)C2=COC3=C(C(=C(C=C3C2=O)OC)OC)O)O |
| InChI | InChI=1S/C18H16O7/c1-22-13-5-4-9(6-12(13)19)11-8-25-17-10(15(11)20)7-14(23-2)18(24-3)16(17)21/h4-8,19,21H,1-3H3 |
| InChI Key | CFAKQDITHIYGEK-UHFFFAOYSA-N |
Properties
| Boiling Point | 587.0 °C at 760 mmHg |
| Density | 1.387 g/cm3 |
| Solubility | Soluble in Ethanol |
Reference Reading
1. New isoflavones, inhibiting catechol-O-methyltransferase, produced by Streptomyces
H Chimura, T Sawa, Y Kumada, H Naganawa, M Matsuzaki J Antibiot (Tokyo). 1975 Sep;28(9):619-26. doi: 10.7164/antibiotics.28.619.
In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3',5,7-trihydroxy-4',6-dimethoxyisoflavone (I), 3',5,7-trihydroxy-4',8-dimethoxyisoflavone (II), 3',8-dihydroxy-4',6,7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
