3-Demethoxy-3-ethoxytetracenomycin C
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-00810 |
| CAS | 79495-72-0 |
| Molecular Weight | 486.42 |
| Molecular Formula | C24H22O11 |
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Description
40 3-Demethoxy-3-ethoxytetracenomycin C is an antibiotic produced by the Ethionine resistant mutant Tu 49 R 39-101 of Streptomyces glaucescens in the presence of DL-ethionine.
Specification
| Synonyms | 3-Detc |
| IUPAC Name | methyl 8-ethoxy-6a,7,10a,12-tetrahydroxy-3-methoxy-1-methyl-6,10,11-trioxo-7H-tetracene-2-carboxylate |
| Canonical SMILES | CCOC1=CC(=O)C2(C(=O)C3=C(C=C4C=C(C(=C(C4=C3O)C)C(=O)OC)OC)C(=O)C2(C1O)O)O |
| InChI | InChI=1S/C24H22O11/c1-5-35-13-8-14(25)23(31)21(29)17-11(19(27)24(23,32)20(13)28)6-10-7-12(33-3)16(22(30)34-4)9(2)15(10)18(17)26/h6-8,20,26,28,31-32H,5H2,1-4H3 |
| InChI Key | MWOGLUWVPFOVLI-UHFFFAOYSA-N |
Properties
| Appearance | Light Yellow Powder |
| Boiling Point | 793.3°C at 760 mmHg |
| Density | 1.61 g/cm3 |
Reference Reading
1. The influence of antioxidants and cycloheximide on the level of nitric oxide in the livers of mice in vivo
V D Mikoyan, N V Voevodskaya, L N Kubrina, I V Malenkova, A F Vanin Biochim Biophys Acta. 1995 Oct 19;1269(1):19-24. doi: 10.1016/0167-4889(95)00092-7.
When injected into mice prior to the NO generation increase induced with lipopolysaccharide (LPS) from Escherichia coli, exogenous antioxidants diethyldithiocarbamate (DETC) or phenazan (sodium 3.5-di-tert-butyl-4-oxiphenylpropionate) as well as the inhibitor of protein biosynthesis, cycloheximide (CHI) attenuated the NO production in mouse liver in vivo. These data demonstrated the key role of free radicals, which were likely, active oxygen species, in the synthesis of inducible NO-synthase (iNOS) responsible for the NO production in this organ. Similar effects of phenazan and CHI were observed in livers of mice treated with gamma-irradiation or LPS + Fe(2+)-citrate, which suggested that these treatments also induced 1NOS synthesis through initiating the action of active oxygen species. The rate of NO synthesis was estimated by accumulation of paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC) detected using the EPR method. The formation of MNIC-DETC complexes was found in the brain of mice pre-treated with LPS + Fe(2+)-citrate which seemed to be due to iNOS synthesis stimulated by this treatment.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
