4-Hydroxypulvinic dilactone
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| Category | Others |
| Catalog number | BBF-04803 |
| CAS |
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Reference Reading
1. Bioactive terpenoids from Croton laui
Fei Li, Dong-Bo Zhang, Jing-Tao Li, Feng-Jie He, Hong-Li Zhu, Nan Li, Xin-Chun Xiao, Li Ren, Wei Zheng Nat Prod Res. 2021 Sep;35(17):2849-2857. doi: 10.1080/14786419.2019.1675062. Epub 2019 Oct 9.
Two new highly-oxygenated neo-clerodane diterpenoids, 3S-acetoxyl-mollotucin D dilactone ester (1) and 6S-crotoeurin C (2), and a new lupane-type triterpene, 16β-hydroxyl-3β-O-trans-coumaroyl-betulin (6), as well as three known analogues (3-5) were obtained from the leaves of Croton laui. The structures of the new compounds were determined by extensive spectroscopic methods, and their absolute configurations were determined by combination of single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) spectra, and literature data. Compounds 2 and 3 exhibited inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 1.2 and 1.6 μM, respectively. Additionally, compound 6 exhibited activity against Col205 and HepG2 cell lines with IC50 values of 12.9 and 17.7 μM, respectively.
2. Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential
Javad Sharifi-Rad, Cristina Quispe, Carla Marina Salgado Castillo, Rodrigo Caroca, Marco A Lazo-Vélez, Halyna Antonyak, Alexandr Polishchuk, Roman Lysiuk, Petro Oliinyk, Luigi De Masi, Paola Bontempo, Miquel Martorell, Sevgi Durna Daştan, Daniela Rigano, Michael Wink, William C Cho Oxid Med Cell Longev. 2022 Feb 21;2022:3848084. doi: 10.1155/2022/3848084. eCollection 2022.
Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
3. New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm
Nor Akmalazura Jani, Hasnah Mohd Sirat, Farediah Ahmad, Nurul Iman Aminudin Nat Prod Res. 2022 Aug;36(16):4061-4069. doi: 10.1080/14786419.2021.1961134. Epub 2021 Aug 3.
One new sesquiterpene dilactone, coccinine (1) and one new β-carboline alkaloid, daibucarboline F (2) together with 10 known compounds; linderane (3), linderalactone (4), pseudoneolinderane (5), linderanlide C (6), linderanine A (7), epicatechin (8), (-)-taxifolin (9), astilbin (10), L-quercitrin (11) and afzelin (12) were isolated from the stems and leaves of Neolitsea cassia (L.) Kosterm (Lauraceae). The structures of (1 and 2) were established by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in literature. The relative stereochemistry of compound (1) was assigned by X-ray diffraction analysis with Cu-Kα irradiation. Compounds (3-8) and (10) were evaluated for their α-glucosidase enzymatic inhibitory activity. Compounds (4-6), (8) and (10) exhibited inhibition towards α-glucosidase enzymatic activity with IC50 values ranging from 12.10 to 96.77 μM. This is the first report on the isolation of phytochemicals from N. cassia and their bioactivities.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
